QQ客服 官方微博 反馈留言

	New Variable Scaling Method for NMR-based Metabolomics Data Analysis; 核磁共振代谢组学数据的尺度归一化新方法
	Dong, J. Y. ; Li, W. ; Deng, L. L. ; Xu, J. J. ; Griffin, J. L. ; Chen, Z. ; Dong JY(董继扬)
	2011-02-10
关键词	METABONOMICS URINE SPECTROSCOPY RATS
英文摘要	Variable scaling is an important data pre-processing step in NMR metabolomics, especially for biomarkers identification. It aims to make the subsequent multivariate analysis more reliable and easier by highlighting the biomarkers-related variables, and reducing the contamination of the noise and irrelevant variables. A new scaling method is proposed in this paper. The proposed method adjusts the weight of variables by their significance and stabilities in order to enhance the variable probably related to signature metabolites. Both of simulated dataset and real metabolomic dataset are used to estimate the performance of the proposed method. Comparing with Unit variance (UV), Variable stability (VAST) and Level scaling (LS) methods, the new scaling method would be robust to preserve molecular information of NMR spectra, improving the predictive ability of multivariate statistical model and making the results of subsequent analysis more interpretable. Therefore, the method proposed herein is more suitable for biomarker identification.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/69784]
专题	物理技术－已发表论文
推荐引用方式 GB/T 7714	Dong, J. Y.,Li, W.,Deng, L. L.,et al. New Variable Scaling Method for NMR-based Metabolomics Data Analysis, 核磁共振代谢组学数据的尺度归一化新方法[J],2011.
APA	Dong, J. Y..,Li, W..,Deng, L. L..,Xu, J. J..,Griffin, J. L..,...&董继扬.(2011).New Variable Scaling Method for NMR-based Metabolomics Data Analysis..
MLA	Dong, J. Y.,et al."New Variable Scaling Method for NMR-based Metabolomics Data Analysis".(2011).

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。