Brownian diffusion of ion channels in different membrane patch geometries

CORC > 厦门大学 > 物理技术－已发表论文

	Brownian diffusion of ion channels in different membrane patch geometries
	Wei, F. ; Yang, D. P. ; Straube, R. ; Shuai, J. W. ; Shuai JW(帅建伟)
刊名	http://dx.doi.org/10.1103/PhysRevE.83.021919
	2011-02-28
关键词	1ST PASSAGE TIME INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR NARROW ESCAPE ENDOPLASMIC-RETICULUM CA2+ RELEASE ASYMPTOTIC ANALYSIS IP3 RECEPTORS EIGENVALUE DOMAINS SPHERE
英文摘要	Ministry of Education of Saxony-Anhalt within the research center Dynamic Systems; National Science Foundation of China [10775114, 30970970]; NIH US [2RO1GM065830-06A1]; We asymptotically calculate the spatially averaged mean first passage time (MFPT) of a diffusing channel protein in a finite membrane patch containing a small absorbing anchor site. Different two-dimensional membrane geometries are considered including a circular, a square-shaped, a rectangular, and a cylindrical domain. The asymptotic expressions are found to be in excellent agreement with results from Monte Carlo simulations if the radius of the diffusing protein is sufficiently small. For a larger radius, a simple correction to the asymptotic expressions is proposed. We show that the average MFPT for a circle and a square-shaped domain of the same area are approximately equal as long as the anchor site is close to the center of the domain. We also discuss how the average MFPT depends on the aspect ratio of a rectangular and a cylindrical domain. Among such domains with a fixed area, a minimal MFPT is obtained for the square-shaped domain.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/69064]
专题	物理技术－已发表论文
推荐引用方式 GB/T 7714	Wei, F.,Yang, D. P.,Straube, R.,et al. Brownian diffusion of ion channels in different membrane patch geometries[J]. http://dx.doi.org/10.1103/PhysRevE.83.021919,2011.
APA	Wei, F.,Yang, D. P.,Straube, R.,Shuai, J. W.,&帅建伟.(2011).Brownian diffusion of ion channels in different membrane patch geometries.http://dx.doi.org/10.1103/PhysRevE.83.021919.
MLA	Wei, F.,et al."Brownian diffusion of ion channels in different membrane patch geometries".http://dx.doi.org/10.1103/PhysRevE.83.021919 (2011).