Intercellular calcium waves in glial cells with bistable dynamics

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	Intercellular calcium waves in glial cells with bistable dynamics
	Wei, F. ; Shuai, J. W. ; Shuai JW(帅建伟)
刊名	http://dx.doi.org/10.1088/1478-3975/8/2/026009
	2011-04
关键词	INOSITOL (1,4,5)-TRISPHOSPHATE 2-DIMENSIONAL MODEL KINETIC-MODEL GAP-JUNCTIONS ASTROCYTES OSCILLATIONS PROPAGATION COMMUNICATION GLUTAMATE RECEPTOR
英文摘要	Ministry of Education of China [108075]; National Science Foundation of China [10775114, 30970970]; A two-dimensional model is proposed for intercellular calcium (Ca(2+)) waves with Ca(2+)-induced IP(3) regeneration and the diffusion of IP(3) through gap junctions. Many experimental observations in glial cells, i.e. responding to local mechanical stimulation, glutamate application, mechanical stimulation followed by ACh application, and glutamate followed by mechanical stimulation, are reproduced and classified by the model. We show that a glial cell model with bistable dynamics, i.e. a Ca(2+) oscillation state coexisting with a fixed point, can cause a prolonged plateau of Ca(2+) signals in the cells nearby the stimulated cell when the cell network responds to the local mechanical stimulation.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/69051]
专题	物理技术－已发表论文
推荐引用方式 GB/T 7714	Wei, F.,Shuai, J. W.,Shuai JW. Intercellular calcium waves in glial cells with bistable dynamics[J]. http://dx.doi.org/10.1088/1478-3975/8/2/026009,2011.
APA	Wei, F.,Shuai, J. W.,&帅建伟.(2011).Intercellular calcium waves in glial cells with bistable dynamics.http://dx.doi.org/10.1088/1478-3975/8/2/026009.
MLA	Wei, F.,et al."Intercellular calcium waves in glial cells with bistable dynamics".http://dx.doi.org/10.1088/1478-3975/8/2/026009 (2011).