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	Nonlinear dynamic properties of low calcium induced epileptiform activity
	Lian, J. ; Shuai, J. ; Durand, D. M. ; Shuai JW(帅建伟)
	2000
关键词	epileptiform activity Lyapunov exponent
英文摘要	The study of dynamic properties of epileptiform can help understand the mechanism of seizure initiation and synchronization. It would be a useful tool to predict the onset of seizure. In this project, we induced epileptiform activity in rat hippocampal brain slices by reducing [Ca2+] (0). The low calcium model of epilepsy is particularly interesting since neurons can synchronize in the absence of synaptic transmission. DC electric fields were applied on the slice to modulate neuronal activity. Lyapunov exponent, global embedding dimension and the local dimension were calculated for two experiment conditions: (1) epileptiform activity formation course: from onset, transition state to completed developed state; (2) in the presence of various level DC electric fields. The global and local dimensions increased rapidly when low calcium induced epileptiform activity was initiated, but it did not change after that, even in the presence of the electric field. The Lyapunov exponent increased during the activity formation process and during application of small, hyperpolarizing electric fields, but decreased when the applied electric field is big enough to partially suppress the activity. These findings suggest that the maximum Lyapunov exponent can be a good method for distinguishing states of the systems and might be important in seizure prediction and control.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/69034]
专题	物理技术－已发表论文
推荐引用方式 GB/T 7714	Lian, J.,Shuai, J.,Durand, D. M.,et al. Nonlinear dynamic properties of low calcium induced epileptiform activity[J],2000.
APA	Lian, J.,Shuai, J.,Durand, D. M.,&帅建伟.(2000).Nonlinear dynamic properties of low calcium induced epileptiform activity..
MLA	Lian, J.,et al."Nonlinear dynamic properties of low calcium induced epileptiform activity".(2000).

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