Quantifying Effect of Intraplaque Hemorrhage on Critical Plaque Wall Stress in Human Atherosclerotic Plaques Using Three-Dimensional Fluid-Structure Interaction Models

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	Quantifying Effect of Intraplaque Hemorrhage on Critical Plaque Wall Stress in Human Atherosclerotic Plaques Using Three-Dimensional Fluid-Structure Interaction Models
	Huang, Xueying ; Yang, Chun ; Canton, Gador ; Ferguson, Marina ; Yuan, Chun ; Tang, Dalin ; Huang XY(黄雪莹)
刊名	http://dx.doi.org/10.1115/1.4007954
	2012-12
关键词	IN-VIVO MRI FIBROUS-CAP THICKNESS RISK-ASSESSMENT STRATEGIES HUMAN CAROTID PLAQUES HIGH-RESOLUTION MRI VULNERABLE PLAQUE FSI MODELS CIRCUMFERENTIAL STRESS SHEAR-STRESS RUPTURE
英文摘要	NSF [DMS-0540684]; NIH [R01 EB004759]; National Natural Science Foundation of China [31100670, 11071203]; Natural Science Foundation of Fujian Province of China [2011J05008]; Fundamental Research Funds for the Central Universities [2012121003]; Recent magnetic resonance studies have indicated that intraplaque hemorrhage (IPH) may accelerate plaque progression and play an important role in plaque destabilization. However, the impact of hemorrhage on critical plaque wall stress (CPWS) and strain (CPWSn) has yet to be determined. The objective of this study was to assess the effect of the presence and size of IPH on wall mechanics. The magnetic resonance image (MRI) of one patient with histology-confirmed IPH was used to build eight 3D fluid-structure interaction (FSI) models by altering the dimensions of the existing IPH. As a secondary end point, the combined effect of IPH and fibrous cap thickness (FCT) was assessed. A volume curve fitting method (VCFM) was applied to generate a mesh that would guarantee numerical convergence. Plaque wall stress (PWS), strain (PWSn), and flow shear stress (FSS) were extracted from all nodal points on the lumen surface for analysis. Keeping other conditions unchanged, the presence of intraplaque hemorrhage caused a significant increase (27.5%) in CPWS; reduced FCT caused an increase of 22.6% of CPWS. Similar results were found for CPWSn. Furthermore, combination of IPH presence, reduced FCT, and increased IPH volume caused an 85% and 75% increase in CPWS and CPWSn, respectively. These results show that intraplaque hemorrhage has considerable impact on plaque stress and strain conditions and accurate quantification of IPH could lead to more accurate assessment of plaque vulnerability. Large-scale studies are needed to further validate our findings. [DOI: 10.1115/1.4007954]
语种	英语
出版者	J BIOMECH ENG-T ASME
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/91136]
专题	数学科学－已发表论文
推荐引用方式 GB/T 7714	Huang, Xueying,Yang, Chun,Canton, Gador,et al. Quantifying Effect of Intraplaque Hemorrhage on Critical Plaque Wall Stress in Human Atherosclerotic Plaques Using Three-Dimensional Fluid-Structure Interaction Models[J]. http://dx.doi.org/10.1115/1.4007954,2012.
APA	Huang, Xueying.,Yang, Chun.,Canton, Gador.,Ferguson, Marina.,Yuan, Chun.,...&黄雪莹.(2012).Quantifying Effect of Intraplaque Hemorrhage on Critical Plaque Wall Stress in Human Atherosclerotic Plaques Using Three-Dimensional Fluid-Structure Interaction Models.http://dx.doi.org/10.1115/1.4007954.
MLA	Huang, Xueying,et al."Quantifying Effect of Intraplaque Hemorrhage on Critical Plaque Wall Stress in Human Atherosclerotic Plaques Using Three-Dimensional Fluid-Structure Interaction Models".http://dx.doi.org/10.1115/1.4007954 (2012).