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	国产胸腺肽治疗慢性乙肝疗效及其机理初探; CLINICAL TREATMENT of CHRONICAL HEPATITIS B BY NATIONAL THYMOSIN AND ITS MECHANISM
	陈国良 ; 欧阳丽娟 ; 吴晓鹭 ; 颜江华 ; 宋思扬 ; 苏文金
	1999
关键词	胸腺肽 ALT HBVDNACD抗原 Thymosin\ ALT HBV DNA\ CD-antigen
英文摘要	本文观察大剂量胸腺肽对慢性乙肝患者的治疗作用并研究其作用机理。用ElISA、PCr 和免疫化学染色法等比较分析胸腺肽治疗三个月后，AlT、HbV- M 和HbV dnA 等指标变化，发现患者AlT 复常率、HbEAg 转阴率、HbV dnA 阴转率和HbV dnA 有效下降率分别为58.33 % 、33.33 % 、41.67 % 和91.67 % ；同时患者外周血Cd4 ＋淋巴细胞亚群上调，Cd8 ＋ 亚群下调，二者比值趋于正常。说明国产胸腺肽治疗慢性乙肝有较好的应用前景，其治疗机理与免疫调节作用有关。; The purpose of this paper was to observe the effects of clinical treatment of chronic hepatitis B by national thymosin and study its machanisms The parameters of HBV-M,HBV DNA and CD-antigens of T cells were detected by ELISA,PCR and immunochemical dying assay after three months of the thymosin treatment The rates of normal-turning of ALT,negative-turning of HBeAg, negative-turning of HBV DNA, and effective downing of HBV DNA in patients with chronic hepatitis B were 58 33%, 33 33%, 41 67%,and 91 67%,respectively At the same time,T CD4 + cells in the peripheral blood of patients was up-regulated,T CD8 + was down-regulated;and ratio of CD4 +/CD8 + is tend to be normal These findings showed that thymosin had a proposing feature in the treatment of chronic hepatitis B and its mechanism may be related to immuno-regulation; 厦门市科委资助课题
语种	zh_CN
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/119572]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	陈国良,欧阳丽娟,吴晓鹭,等. 国产胸腺肽治疗慢性乙肝疗效及其机理初探, CLINICAL TREATMENT of CHRONICAL HEPATITIS B BY NATIONAL THYMOSIN AND ITS MECHANISM[J],1999.
APA	陈国良,欧阳丽娟,吴晓鹭,颜江华,宋思扬,&苏文金.(1999).国产胸腺肽治疗慢性乙肝疗效及其机理初探..
MLA	陈国良,et al."国产胸腺肽治疗慢性乙肝疗效及其机理初探".(1999).

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