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	乙型肝炎IgM和IgG-补体双特异性循环免疫复合物的意义; SIGNIFICANCE of Ig (IgM AND IgG) AND C 3 COMPONENT-DETERMINED CIRCULATING IMMUNE COMPLEXES IN HBV INFECTED PATIENTS
	彭宣宪 ; 王三英 ; 黄雪芳
	1997
关键词	乙型肝炎 循环免疫复合物 免疫球蛋白 补体 Hepatitis B Circulating immune complex Immunoglobulin Complement
英文摘要	对不同临床类型的乙型肝炎患者，采用捕捉法ElISA，以IgM和Igg类抗体排除抗原性异物的免疫反应进行比较研究。结果发现，两种反应能力在慢性HbV感染中基本相同，表现出明显的病型差异，而在急性HbV感染中则不同，前者反应强度显著高于后者；二者阳性率在慢性HbV感染的临床类型中虽均随其肝损害加重而显著上升，但Igg/C3双特异性循环免疫复合物（TCIC）与AlT有关，而IgM/C3-TCIC与AlT无关；二者阳性率与C4的关系亦不同。这些结果提示，IgM和Igg/补体-TCIC的病理意义不同，免疫复合物的异质性值得注意。; By a capture-ELISA method,the immune responses of IgM and IgG classes to the clearness of antigens in the Form of immune complex had been comparatively determined by the detection of IgM/C3-TCIC (two-component-determined circulating immune complexes,TCIC) and IgG/C 3-TCIC in diFFerent clinical types of hepatitis B virus (HBV) inFections including 41 asymptomatic HBsAg carriers,55 acute hepatitis B,54 chronic persistent hepatitis B.55 chronic activ ehepatitis B,18 hepatic Failure of hepatitis B and 52 cirrhosis aFter hepatitis B.We interestingly Found although the two Forms were similar in chronic HBV inFections with the signiFicant diFFerences among their clinical types,both were diFFerent in acute HBV inFection with the signiFicantly higher positive rates of IgM/C 3-TCIC over those of IgG/C 3-TCIC.Our data also showed that the relationships of ALT with the positive rates revealed IgG/C 3-TCIC played an important role in liver damage but IgM/C 3-TCIC did not,both positive rates were positively associated with the degree of damaged liver of diFFerent clinical types of chronic HBV inFections.Furthermore,IgG/C 3-TCIC related to serum C 4 but IgM/C 3-TCIC did not.These Findings suggest that the signiFicances of both IgM/C 3-TCIC and IgG/C 3-TCIC are not the same in pathology and physiology,which reminds us of paying attention to the study of heterologous immune complexes.; 国家自然科学基金;国家教委留学生基金
语种	zh_CN
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/119408]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	彭宣宪,王三英,黄雪芳. 乙型肝炎IgM和IgG-补体双特异性循环免疫复合物的意义, SIGNIFICANCE of Ig (IgM AND IgG) AND C 3 COMPONENT-DETERMINED CIRCULATING IMMUNE COMPLEXES IN HBV INFECTED PATIENTS[J],1997.
APA	彭宣宪,王三英,&黄雪芳.(1997).乙型肝炎IgM和IgG-补体双特异性循环免疫复合物的意义..
MLA	彭宣宪,et al."乙型肝炎IgM和IgG-补体双特异性循环免疫复合物的意义".(1997).

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