| 体外γ-干扰素检测结核分枝杆菌不同方法的应用价值比较; Value of in vitro IFN-γ release assay in detection of Mycobacterium tuberculosis | |
| 李晓非 ; 李明武 ; 苏俊华 ; 周敏 ; 杨飞 ; 李惠敏 ; 熊俊辉 | |
| 2012 | |
| 关键词 | γ-干扰素释放反应 结核分枝杆菌 结核病 诊断 Interferon-gamma release assay Mycobacterium tuberculosis Tuberculosis Diagnosis |
| 英文摘要 | 目的探讨结核分枝杆菌相关γ-干扰素体外释放(Tb-IgrA)定量试验,对于结核病诊断的应用价值。方法用国产Tb-IgrA试剂定量检测342例结核病患者、143例非结核病患者外周血特异性γ-干扰素的含量,同时与澳大利亚QfT gIT和英国牛津T-SPOT.Tb试剂进行平行比较分析。结果 Tb-IgrA试剂对结核病患者的检测阳性率为90.1%,且对肺结核与肺外结核的检测差异无统计学意义,检测结果不受bCg的影响,与QfT gIT和T-SPOT.Tb试剂比较,3种方法差异无统计学意义。结论 Tb-IgrA检测结核分枝杆菌有较高的敏感性,对于结核病的诊断及预防有较好的应用价值。; OBJECTIVE To evaluate the application value of MTB related IFN-γ release assay(TB-IGRA) for the diagnosis of tuberculosis.METHODS We detected the specific IFN-γ content in peripheral blood of 342 tuberculosis patients and 143 non-tubercular people with homebred TB-IGRA,in the meantime,did the same detections with QFT GIT from Australia and T-SPOT.TB from Oxford UK as parallel controls.RESULTS The positive rate of TB patients was 90.1% with TB-IGRA,and there were no significant differences between the detection of pulmonary tuberculosis and extrapulmonary tuberculosis,without BCG affecting this,as compared with QFT GIT and T-SPOT.TB,there were no significant differences among the 3 methods.CONCLUSION TB-IGRA has high sensitivity to the detection of Mycobacterium tuberculosis and preferable application value in the diagnosis and prevention of tuberculosis.; 传染病重大专项(2008ZX10003-004) |
| 语种 | zh_CN |
| 内容类型 | 期刊论文 |
| 源URL | [http://dspace.xmu.edu.cn/handle/2288/119155]  |
| 专题 | 生命科学－已发表论文 |
| 推荐引用方式 GB/T 7714 | 李晓非,李明武,苏俊华,等. 体外γ-干扰素检测结核分枝杆菌不同方法的应用价值比较, Value of in vitro IFN-γ release assay in detection of Mycobacterium tuberculosis[J],2012. |
| APA | 李晓非.,李明武.,苏俊华.,周敏.,杨飞.,...&熊俊辉.(2012).体外γ-干扰素检测结核分枝杆菌不同方法的应用价值比较.. |
| MLA | 李晓非,et al."体外γ-干扰素检测结核分枝杆菌不同方法的应用价值比较".(2012). |
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