| 胚胎着床过程中的前列腺素调控网络; Network Regulation of Prostaglandin Pathway during Embryo Implantation | |
| 赵振奥 ; 杨增明 | |
| 2011 | |
| 关键词 | 着床 前列腺素 β-catenin HB-EGF STAT3 implantation prostaglandin β-catenin HB-EGF STAT3 |
| 英文摘要 | 已证实与前列腺素代谢相关的COX-2、CPlA_(2α)或lPAr3基因敲除的小鼠都表现为着床延迟,而着床前注射前列腺素可以挽救胚胎着床,表明前列腺素在胚胎着床过程中起重要作用。越来越多的证据表明,前列腺素可以通过CAMP/PkA和PI3k/AkT通路活化β-CATEnIn,又可以通过基质金属蛋白酶(MATrIX METAllOPrOTEInASE,MMP)活化肝素结合类表皮生长因子(HEPArIn-bIndIng Egf-lIkEgrOWTH fACTOr,Hb-Egf),还可以通过SrC和Il-6活化信号传导与转录激活因子3(SIgnAl TrAnSduCEr AndACTIVATOr Of TrAnSCrIPTIOn 3,STAT3)。而这些分子活化后又可上调COX-2。此外,前列腺素相关分子内部也存在着正反馈调节。这几个通路之间的相互作用形成了一个网络,在胚胎着床过程中可能发挥重要作用。; Prostaglandin(PG) could rescue delayed implantation deficiencies in Cox-2-,cPLA_(2α)- or Lpar3- deficient mice,respectively,suggesting that prostaglandin was important for implantation.PG could activate P-catenin through cAMP/PKA and PI3K/AKT,activate heparin-binding EGF-like growth factor(HB-EGF) pathway through matrix metalloproteinase cleavage and activate signal transducer and activator of transcription 3(STAT3) through Src and IL-6.At the same time,COX-2 could be up-regulated byβ-catenin,HB-EGF and STAT3.The genes in prostaglandin pathway could also form a positive feedback loop.The interactions among these pathways form a network,which may play important roles during embryo implantation. |
| 语种 | zh_CN |
| 内容类型 | 期刊论文 |
| 源URL | [http://dspace.xmu.edu.cn/handle/2288/119091]  |
| 专题 | 生命科学－已发表论文 |
| 推荐引用方式 GB/T 7714 | 赵振奥,杨增明. 胚胎着床过程中的前列腺素调控网络, Network Regulation of Prostaglandin Pathway during Embryo Implantation[J],2011. |
| APA | 赵振奥,&杨增明.(2011).胚胎着床过程中的前列腺素调控网络.. |
| MLA | 赵振奥,et al."胚胎着床过程中的前列腺素调控网络".(2011). |
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