Chronic Exposure to Phenanthrene Influences the Spermatogenesis of Male Sebastiscus marmoratus: U-Shaped Effects and the Reason for Them

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	Chronic Exposure to Phenanthrene Influences the Spermatogenesis of Male Sebastiscus marmoratus: U-Shaped Effects and the Reason for Them
	Sun, Lingbin ; Zuo, Zhenghong ; Luo, Hongmin ; Chen, Meng ; Zhong, Yuanfu ; Chen, Yixin ; Wang, Chonggan ; Zuo ZH(左正宏)
刊名	http://dx.doi.org/10.1021/es202684w
	2011-12-01
关键词	POLYCYCLIC AROMATIC-HYDROCARBONS GONADOTROPIN-RELEASING-HORMONE FLOUNDER PLATICHTHYS-FLESUS ZEBRAFISH DANIO-RERIO PITUITARY-GONAD AXIS CARASSIUS-AURATUS RISK-ASSESSMENT DOSE-RESPONSE GENE-EXPRESSION MESSENGER-RNA
英文摘要	National Natural Science Foundation of China [40476049]; Natural Scientific Fund of Fujian Province, China [2009J01225]; Program for Changjiang Scholars and Innovative Research Team in University [IRT0941]; Phenanthrene (PHE) is one of the most abundant polycyclic aromatic hydrocarbons in the aquatic environment. This study was conducted to investigate the effects of PHE at environmentally relevant concentrations on testicular development in male Sebastiscus marmoratus. After SO days exposure, the gonadosomatic indices and percentage of sperm produced showed a U-shaped dose response. The levels of salmon-type gonadotropin releasing hormone, follicle-stimulating hormone, luteinizing hormone mRNA, 17 beta-estradiol, and gamma-glutamyl transpeptidase activity all showed a U-shaped dose response, which dearly demonstrated the U-shaped effects of PHE exposure on spermatogenesis and also elucidated the action pathway. This result would bring a difficulty and a challenge to any risk assessment of PHE exposure to the reproductive health of fishes. Thus far, there has been no ready explanation for a U-shaped dose-response curve, which is well recognized as a hormetic phenomenon for many hormones, drugs, and toxic compounds. In the present study, PHE accumulation in the brain showed an inverse U-shaped increase compared to the control. Glutathione S-transferase activity in the brain showed a U-shaped dose-response, which was related with the PHE accumulation. These results have given a reasonable explanation for the U-shaped dose-response via alteration of biotransformation enzyme activity in the brain.
语种	英语
出版者	American Chemical Society
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/90908]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Sun, Lingbin,Zuo, Zhenghong,Luo, Hongmin,et al. Chronic Exposure to Phenanthrene Influences the Spermatogenesis of Male Sebastiscus marmoratus: U-Shaped Effects and the Reason for Them[J]. http://dx.doi.org/10.1021/es202684w,2011.
APA	Sun, Lingbin.,Zuo, Zhenghong.,Luo, Hongmin.,Chen, Meng.,Zhong, Yuanfu.,...&左正宏.(2011).Chronic Exposure to Phenanthrene Influences the Spermatogenesis of Male Sebastiscus marmoratus: U-Shaped Effects and the Reason for Them.http://dx.doi.org/10.1021/es202684w.
MLA	Sun, Lingbin,et al."Chronic Exposure to Phenanthrene Influences the Spermatogenesis of Male Sebastiscus marmoratus: U-Shaped Effects and the Reason for Them".http://dx.doi.org/10.1021/es202684w (2011).