Biosynthesis of Hygrocins, Antitumor Naphthoquinone Ansamycins Produced by Streptomyces sp LZ35 | |
Li, Shanren ; Wang, Haoxin ; Li, Yaoyao ; Deng, Jingjing ; Lu, Chunhua ; Shen, Yan ; Shen, Yuemao ; Wang HX(王浩鑫) ; Lu CH(鲁春华) ; Shen YM(沈月毛) | |
刊名 | http://dx.doi.org/10.1002/cbic.201300599
![]() |
2014-01-03 | |
关键词 | GENE-CLUSTER GELDANAMYCIN BIOSYNTHESIS ACTINOSYNNEMA-PRETIOSUM NATURAL-PRODUCTS RIFAMYCIN IDENTIFICATION HYGROSCOPICUS ANSAMITOCIN CHEMISTRY SYNTHASE |
英文摘要 | National Natural Science Foundation of China [31100079]; IIFSDU [2013GN014]; 973 Programs [2010CB833802, 2012CB721005]; Hygrocins are naphthoquinone ansamycins with significant antitumor activities. Here, we report the identification and characterization of the hygrocin biosynthetic gene cluster (hgc) in Streptomyces sp. LZ35. A biosynthetic pathway is proposed based on bioinformatics analysis of the hgc genes and intermediates accumulated in selected gene disruption mutants. One of the steps during the biosynthesis of hygrocins is a Baeyer-Villiger oxidation between C5 and C6, catalyzed by luciferase-like monooxygenase homologue Hgc3. Hgc3 represents the founding member of a previously uncharacterized family of enzymes acting as Baeyer-Villiger monooxygenases. |
语种 | 英语 |
出版者 | WILEY-V C H VERLAG GMBH |
内容类型 | 期刊论文 |
源URL | [http://dspace.xmu.edu.cn/handle/2288/90848] ![]() |
专题 | 生命科学-已发表论文 |
推荐引用方式 GB/T 7714 | Li, Shanren,Wang, Haoxin,Li, Yaoyao,et al. Biosynthesis of Hygrocins, Antitumor Naphthoquinone Ansamycins Produced by Streptomyces sp LZ35[J]. http://dx.doi.org/10.1002/cbic.201300599,2014. |
APA | Li, Shanren.,Wang, Haoxin.,Li, Yaoyao.,Deng, Jingjing.,Lu, Chunhua.,...&沈月毛.(2014).Biosynthesis of Hygrocins, Antitumor Naphthoquinone Ansamycins Produced by Streptomyces sp LZ35.http://dx.doi.org/10.1002/cbic.201300599. |
MLA | Li, Shanren,et al."Biosynthesis of Hygrocins, Antitumor Naphthoquinone Ansamycins Produced by Streptomyces sp LZ35".http://dx.doi.org/10.1002/cbic.201300599 (2014). |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论