Biosynthesis of Hygrocins, Antitumor Naphthoquinone Ansamycins Produced by Streptomyces sp LZ35

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	Biosynthesis of Hygrocins, Antitumor Naphthoquinone Ansamycins Produced by Streptomyces sp LZ35
	Li, Shanren ; Wang, Haoxin ; Li, Yaoyao ; Deng, Jingjing ; Lu, Chunhua ; Shen, Yan ; Shen, Yuemao ; Wang HX(王浩鑫) ; Lu CH(鲁春华) ; Shen YM(沈月毛)
刊名	http://dx.doi.org/10.1002/cbic.201300599
	2014-01-03
关键词	GENE-CLUSTER GELDANAMYCIN BIOSYNTHESIS ACTINOSYNNEMA-PRETIOSUM NATURAL-PRODUCTS RIFAMYCIN IDENTIFICATION HYGROSCOPICUS ANSAMITOCIN CHEMISTRY SYNTHASE
英文摘要	National Natural Science Foundation of China [31100079]; IIFSDU [2013GN014]; 973 Programs [2010CB833802, 2012CB721005]; Hygrocins are naphthoquinone ansamycins with significant antitumor activities. Here, we report the identification and characterization of the hygrocin biosynthetic gene cluster (hgc) in Streptomyces sp. LZ35. A biosynthetic pathway is proposed based on bioinformatics analysis of the hgc genes and intermediates accumulated in selected gene disruption mutants. One of the steps during the biosynthesis of hygrocins is a Baeyer-Villiger oxidation between C5 and C6, catalyzed by luciferase-like monooxygenase homologue Hgc3. Hgc3 represents the founding member of a previously uncharacterized family of enzymes acting as Baeyer-Villiger monooxygenases.
语种	英语
出版者	WILEY-V C H VERLAG GMBH
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/90848]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Li, Shanren,Wang, Haoxin,Li, Yaoyao,et al. Biosynthesis of Hygrocins, Antitumor Naphthoquinone Ansamycins Produced by Streptomyces sp LZ35[J]. http://dx.doi.org/10.1002/cbic.201300599,2014.
APA	Li, Shanren.,Wang, Haoxin.,Li, Yaoyao.,Deng, Jingjing.,Lu, Chunhua.,...&沈月毛.(2014).Biosynthesis of Hygrocins, Antitumor Naphthoquinone Ansamycins Produced by Streptomyces sp LZ35.http://dx.doi.org/10.1002/cbic.201300599.
MLA	Li, Shanren,et al."Biosynthesis of Hygrocins, Antitumor Naphthoquinone Ansamycins Produced by Streptomyces sp LZ35".http://dx.doi.org/10.1002/cbic.201300599 (2014).