The aberrant expression and localization of prohibitin during apoptosis of human cholangiocarcinoma Mz-ChA-1 cells

CORC > 厦门大学 > 生命科学－已发表论文

	The aberrant expression and localization of prohibitin during apoptosis of human cholangiocarcinoma Mz-ChA-1 cells
	Song, Wei ; Tian, Ling ; Li, Shan-Shan ; Shen, Dong-Yan ; Chen, Qing-Xi ; Chen QX(陈清西)
刊名	http://dx.doi.org/10.1016/j.febslet.2013.12.021
	2014-01-31
关键词	INDUCED DIFFERENTIATION MITOCHONDRIAL PROTEINS TUMOR-SUPPRESSOR NUCLEAR-MATRIX CANCER CELLS RB CARCINOGENESIS PROLIFERATION FAMILY TARGET
英文摘要	National Science Foundation for Fostering Talents in Basic Research of the National Natural Science Foundation of China [J1310027/J0106]; Science and Technology Foundation of Xiamen, China [3502Z20133009]; National Nature Science Foundation of China [81101502]; In this study, we aimed to investigate the aberrant expression and shift in localization of prohibitin (PHB) during apoptosis of human cholangiocarcinoma cells. Our study demonstrated that PHB was expressed primarily in the cytoplasm and only a little in the nucleus. However, PHB expression significantly decreased, and its localization shifted from the cytoplasm to the nucleus during apoptosis. PHB co-localized with AIF, Rb, p53, and c-Fos, but the region of co-localization was altered after treatment. Meanwhile, we detected a direct interaction between PHB and both p53 and Rb in Mz-ChA-1 cells. These results suggest that the altered localization and expression of PHB, as well as its co-localization with related oncogenes and tumor suppressor genes, can affect the apoptosis of Mz-ChA-1 cells. Structured summary of protein interactions: AIF and PHB colocalize by fluorescence microscopy (View interaction) Rb and PHB colocalize by fluorescence microscopy (View interaction) c-Fos and PHB colocalize by fluorescence microscopy (View interaction) PHB and p53 colocalize by fluorescence microscopy (View interaction) (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
语种	英语
出版者	ELSEVIER SCIENCE BV
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/90840]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Song, Wei,Tian, Ling,Li, Shan-Shan,et al. The aberrant expression and localization of prohibitin during apoptosis of human cholangiocarcinoma Mz-ChA-1 cells[J]. http://dx.doi.org/10.1016/j.febslet.2013.12.021,2014.
APA	Song, Wei,Tian, Ling,Li, Shan-Shan,Shen, Dong-Yan,Chen, Qing-Xi,&陈清西.(2014).The aberrant expression and localization of prohibitin during apoptosis of human cholangiocarcinoma Mz-ChA-1 cells.http://dx.doi.org/10.1016/j.febslet.2013.12.021.
MLA	Song, Wei,et al."The aberrant expression and localization of prohibitin during apoptosis of human cholangiocarcinoma Mz-ChA-1 cells".http://dx.doi.org/10.1016/j.febslet.2013.12.021 (2014).