The role of periostin in tissue remodeling across health and disease

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	The role of periostin in tissue remodeling across health and disease
	Conway, Simon J. ; Izuhara, Kenji ; Kudo, Yasusei ; Litvin, Judith ; Markwald, Roger ; Ouyang, Gaoliang ; Arron, Joseph R. ; Holweg, Cecile T. J. ; Kudo, Akira ; 欧阳高亮
刊名	http://dx.doi.org/10.1007/s00018-013-1494-y
	2014
关键词	CELL-ADHESION MOLECULE PROMOTES TUMOR ANGIOGENESIS DROSOPHILA FASCICLIN-I GROWTH-FACTOR-BETA EXTRACELLULAR-MATRIX INCREASED EXPRESSION PULMONARY-FIBROSIS SEQUENCE-ANALYSIS GENE-EXPRESSION ALLERGIC-ASTHMA
英文摘要	F. Hoffmann-La Roche Ltd; Chugai Pharmaceutical Co. Ltd; Shino-test Co. Ltd; Periostin, also termed osteoblast-specific factor 2, is a matricellular protein with known functions in osteology, tissue repair, oncology, cardiovascular and respiratory systems, and in various inflammatory settings. However, most of the research to date has been conducted in divergent and circumscribed areas meaning that the overall understanding of this intriguing molecule remains fragmented. Here, we integrate the available evidence on periostin expression, its normal role in development, and whether it plays a similar function during pathologic repair, regeneration, and disease in order to bring together the different research fields in which periostin investigations are ongoing. In spite of the seemingly disparate roles of periostin in health and disease, tissue remodeling as a response to insult/injury is emerging as a common functional denominator of this matricellular molecule. Periostin is transiently upregulated during cell fate changes, either physiologic or pathologic. Combining observations from various conditions, a common pattern of events can be suggested, including periostin localization during development, insult and injury, epithelial-mesenchymal transition, extracellular matrix restructuring, and remodeling. We propose mesenchymal remodeling as an overarching role for the matricellular protein periostin, across physiology and disease. Periostin may be seen as an important structural mediator, balancing appropriate versus inappropriate tissue adaption in response to insult/injury.
语种	英语
出版者	SPRINGER BASEL AG
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/90809]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Conway, Simon J.,Izuhara, Kenji,Kudo, Yasusei,et al. The role of periostin in tissue remodeling across health and disease[J]. http://dx.doi.org/10.1007/s00018-013-1494-y,2014.
APA	Conway, Simon J..,Izuhara, Kenji.,Kudo, Yasusei.,Litvin, Judith.,Markwald, Roger.,...&欧阳高亮.(2014).The role of periostin in tissue remodeling across health and disease.http://dx.doi.org/10.1007/s00018-013-1494-y.
MLA	Conway, Simon J.,et al."The role of periostin in tissue remodeling across health and disease".http://dx.doi.org/10.1007/s00018-013-1494-y (2014).