The role of Litopenaeus vannamei p38 in white spot syndrome virus infection

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	The role of Litopenaeus vannamei p38 in white spot syndrome virus infection
	Shi, Hong ; Ruan, Lingwei ; Yan, Xinfu ; Yao, Defu ; Xu, Xun ; Yao DF(姚德福)
刊名	http://dx.doi.org/10.1016/j.dci.2013.12.005
	2014
关键词	MOLECULAR CHARACTERIZATION KINASE MAPK ACTIVATION PATHWAYS JNK IDENTIFICATION BACTERIA SHRIMP ERK
英文摘要	Major State Basic Research Development Program [2012CB114403]; National High Technology Research and Development Program of China [2012AA092205]; National Natural Science Foundation of China [31001125]; China Agriculture Research System-47; Fujian Science and Technology Project [2011J05079]; Scientific Research Foundation of Third Institute of Oceanography, SOA [2011018]; p38 as a member of MAPK family, has been conversed from yeast to mammals. It has been implicated in numerous biological processes, including the responses to stress and inflammation. In this study, three closely related p38 MAPK homologs, Ivp38a, Ivp38b and Ivp38c, which differ only in an internal 25-amino acid sequence, have been cloned from Litopenaeus vannamei. Three isoforms shared p38 conserved TGY motif and catalytic center, as well as had maximum identities to human p38a and Drosophila p38b. Tissue distribution revealed that Ivp38a and Ivp38b were ubiquitously expressed in most tissues, while Ivp38c showed at relatively low levels and in a tissue-specific manner. Western blotting analysis showed that Ivp38 was activated by phosphorylation during WSSV infection. Furthermore, silencing Ivp38 mediated by specific dsRNA in shrimps promoted white spot syndrome virus (WSSV) replication and viral gene transcription at the early stage. These results demonstrated that Ivp38 was involved in WSSV infection and might participate in host defense at the early stage. (C) 2013 Elsevier Ltd. All rights reserved.
语种	英语
出版者	ELSEVIER SCI LTD
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/90791]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Shi, Hong,Ruan, Lingwei,Yan, Xinfu,et al. The role of Litopenaeus vannamei p38 in white spot syndrome virus infection[J]. http://dx.doi.org/10.1016/j.dci.2013.12.005,2014.
APA	Shi, Hong,Ruan, Lingwei,Yan, Xinfu,Yao, Defu,Xu, Xun,&姚德福.(2014).The role of Litopenaeus vannamei p38 in white spot syndrome virus infection.http://dx.doi.org/10.1016/j.dci.2013.12.005.
MLA	Shi, Hong,et al."The role of Litopenaeus vannamei p38 in white spot syndrome virus infection".http://dx.doi.org/10.1016/j.dci.2013.12.005 (2014).