T-Bet and Eomes Regulate the Balance between the Effector/Central Memory T Cells versus Memory Stem Like T Cells

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	T-Bet and Eomes Regulate the Balance between the Effector/Central Memory T Cells versus Memory Stem Like T Cells
	Li, Gang ; Yang, Qianting ; Zhu, Yibei ; Wang, Hong-Rui ; Chen, Xinchun ; Zhang, Xueguang ; Lu, Binfeng ; Wang HR(王洪睿)
刊名	http://dx.doi.org/10.1371/journal.pone.0067401
	2013
关键词	TRANSCRIPTION FACTOR EOMESODERMIN ADOPTIVE IMMUNOTHERAPY COLORECTAL-CANCER VIRAL-INFECTION CUTTING EDGE DIFFERENTIATION METASTASIS COMMITMENT EXPRESSION RESPONSES
英文摘要	NSFC [2010692006, 30930085, 31170866, 81273208]; 973 project [2013CB530501]; Priority Academic Program Development of Jiangsu Higher Education Institution (PAPD); Jiangsu natural science fund [BK2011289]; National Nature Science Foundation of China [81171535]; [1R21CA167229-01A1]; Memory T cells are composed of effector, central, and memory stem cells. Previous studies have implicated that both T-bet and Eomes are involved in the generation of effector and central memory CD8 T cells. The exact role of these transcription factors in shaping the memory T cell pool is not well understood, particularly with memory stem T cells. Here, we demonstrate that both T-bet or Eomes are required for elimination of established tumors by adoptively transferred CD8 T cells. We also examined the role of T-bet and Eomes in the generation of tumor-specific memory T cell subsets upon adoptive transfer. We showed that combined T-bet and Eomes deficiency resulted in a severe reduction in the number of effector/central memory T cells but an increase in the percentage of CD62L(high)CD44(low) Sca-1(+) T cells which were similar to the phenotype of memory stem T cells. Despite preserving large numbers of phenotypic memory stem T cells, the lack of both of T-bet and Eomes resulted in a profound defect in antitumor memory responses, suggesting T-bet and Eomes are crucial for the antitumor function of these memory T cells. Our study establishes that T-bet and Eomes cooperate to promote the phenotype of effector/central memory CD8 T cell versus that of memory stem like T cells.
语种	英语
出版者	PUBLIC LIBRARY SCIENCE
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/90710]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Li, Gang,Yang, Qianting,Zhu, Yibei,et al. T-Bet and Eomes Regulate the Balance between the Effector/Central Memory T Cells versus Memory Stem Like T Cells[J]. http://dx.doi.org/10.1371/journal.pone.0067401,2013.
APA	Li, Gang.,Yang, Qianting.,Zhu, Yibei.,Wang, Hong-Rui.,Chen, Xinchun.,...&王洪睿.(2013).T-Bet and Eomes Regulate the Balance between the Effector/Central Memory T Cells versus Memory Stem Like T Cells.http://dx.doi.org/10.1371/journal.pone.0067401.
MLA	Li, Gang,et al."T-Bet and Eomes Regulate the Balance between the Effector/Central Memory T Cells versus Memory Stem Like T Cells".http://dx.doi.org/10.1371/journal.pone.0067401 (2013).