Sex-different effects of tributyltin on brain aromatase, estrogen receptor and retinoid X receptor gene expression in rockfish (Sebastiscus marmoratus)

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	Sex-different effects of tributyltin on brain aromatase, estrogen receptor and retinoid X receptor gene expression in rockfish (Sebastiscus marmoratus)
	Zhang, Jiliang ; Zuo, Zhenghong ; Zhu, Wenwen ; Sun, Ping ; Wang, Chonggang ; Zuo ZH(左正宏) ; Sun P(孙萍) ; Wang ZG(王重刚)
刊名	http://dx.doi.org/10.1016/j.marenvres.2013.06.004
	2013
关键词	MEDAKA ORYZIAS-LATIPES ZEBRAFISH DANIO-RERIO ORGANOTIN COMPOUNDS ENDOCRINE DISRUPTION ENVIRONMENTAL LEVELS MARINE-ENVIRONMENT COASTAL AREA FISH EXPOSURE IMPOSEX
英文摘要	National Natural Science Foundation, China [20777061]; Educational Commission of Henan Province, China [12B240001]; Since the brain plays important roles in reproduction, the brain aromatase (Cyp19b), estrogen receptor (ER), retinoid X receptor (RXR) alpha and peroxisome proliferator-activated receptor gamma were examined in rockfish after TBT exposure (1, 10, and 100 ng L-1). The results showed that the Cyp19b expression was elevated in the male rockfish, while no effect was produced in the females. Inconsistently, serum testosterone and 17 beta-estradiol showed no change in the males, while an increase of testosterone and a decrease of 17 beta-estradiol were observed in the females. TBT affected the ER expression in the males depending on the concentrations, however, no change was observed in the females. In addition, TBT elevated the RXR alpha expression in the males but produced an opposite effect in the females. In conclusion, TBT might have had sex-different effects on the brain Cyp19b, ER and RXR expression in rockfish, indicating a complex endocrine disrupting effect of TBT. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.
语种	英语
出版者	ELSEVIER SCI LTD
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/90691]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Zhang, Jiliang,Zuo, Zhenghong,Zhu, Wenwen,et al. Sex-different effects of tributyltin on brain aromatase, estrogen receptor and retinoid X receptor gene expression in rockfish (Sebastiscus marmoratus)[J]. http://dx.doi.org/10.1016/j.marenvres.2013.06.004,2013.
APA	Zhang, Jiliang.,Zuo, Zhenghong.,Zhu, Wenwen.,Sun, Ping.,Wang, Chonggang.,...&王重刚.(2013).Sex-different effects of tributyltin on brain aromatase, estrogen receptor and retinoid X receptor gene expression in rockfish (Sebastiscus marmoratus).http://dx.doi.org/10.1016/j.marenvres.2013.06.004.
MLA	Zhang, Jiliang,et al."Sex-different effects of tributyltin on brain aromatase, estrogen receptor and retinoid X receptor gene expression in rockfish (Sebastiscus marmoratus)".http://dx.doi.org/10.1016/j.marenvres.2013.06.004 (2013).