Downregulation of p38 MAPK involved in inhibition of LDL-induced proliferation of mesangial cells and matrix by curcumin

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	Downregulation of p38 MAPK involved in inhibition of LDL-induced proliferation of mesangial cells and matrix by curcumin
	Xia, Ju-mei ; Zhang, Jun ; Zhou, Wen-xiang ; Liu, Xiao-cheng ; Han, Min ; Zhang J(张军)
刊名	http://dx.doi.org/10.1007/s11596-013-1178-8
	2013
关键词	NECROSIS-FACTOR-ALPHA GENE-EXPRESSION CYCLOOXYGENASE-2 APOPTOSIS KIDNEY
英文摘要	National Natural Science Foundation of China [81100485]; Scientific Research Foundation for Returned Scholars, Ministry of Education of China [[2011]1568]; Curcumin, as a main pharmacological component in the traditional Chinese medicine-turmeric, has shown anti-inflammatory, anti-oxidation, anti-tumor and anti-fibrotic effects. This study aimed to investigate the possible underlying signaling pathway which was involved in the inhibition of LDL-induced proliferation of mesangial cells and matrix by curcumin. Rat mesangial cells in vitro were incubated with low-density lipoprotein (LDL) and different concentrations of curcumin (0, 6.25, 12.5, 25.0 mu mol/L) or p38 MAPK inhibitor, SB203580 (10 mu mol/L). Under LDL incubation, mesangial cells proliferated, the expression of MMP-2 mRNA and protein was decreased, the expression of COX-2 mRNA and protein was increased, reactive oxygen species (ROS) generation was increased and p38 MAPK was activated significantly (P < 0.05). When LDL-induced cells were treated with curcumin in the concentration of 12.5 or 25.0 mu mol/L, LDL-induced proliferation of mesangial cells was suppressed, the expression of MMP-2 mRNA and protein increased, the expression of COX-2 mRNA and protein downregulated, the production of ROS inhibited and p38 MAPK inactivated (P < 0.05). In conclusion, curcumin can inhibit the LDL-induced proliferation of mesangial cells and up-regulate the expression of MMP-2, which may be related with the inhibitory effect of curcumin on COX-2 expression, ROS production and p38 MAPK.
语种	英语
出版者	SPRINGER
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/90679]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Xia, Ju-mei,Zhang, Jun,Zhou, Wen-xiang,et al. Downregulation of p38 MAPK involved in inhibition of LDL-induced proliferation of mesangial cells and matrix by curcumin[J]. http://dx.doi.org/10.1007/s11596-013-1178-8,2013.
APA	Xia, Ju-mei,Zhang, Jun,Zhou, Wen-xiang,Liu, Xiao-cheng,Han, Min,&张军.(2013).Downregulation of p38 MAPK involved in inhibition of LDL-induced proliferation of mesangial cells and matrix by curcumin.http://dx.doi.org/10.1007/s11596-013-1178-8.
MLA	Xia, Ju-mei,et al."Downregulation of p38 MAPK involved in inhibition of LDL-induced proliferation of mesangial cells and matrix by curcumin".http://dx.doi.org/10.1007/s11596-013-1178-8 (2013).