Phenanthrene causes ocular developmental toxicity in zebrafish embryos and the possible mechanisms involved

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	Phenanthrene causes ocular developmental toxicity in zebrafish embryos and the possible mechanisms involved
	Huang, Lixing ; Wang, Chonggang ; Zhang, Youyu ; Wu, Meifang ; Zuo, Zhenghong ; Wang ZG(王重刚) ; Zuo ZH(左正宏)
刊名	http://dx.doi.org/10.1016/j.jhazmat.2013.07.030
	2013
关键词	POLYCYCLIC AROMATIC-HYDROCARBONS SEBASTISCUS-MARMORATUS EMBRYOS SALMON ONCORHYNCHUS-GORBUSCHA RETINAL-PIGMENT EPITHELIUM CIGARETTE-SMOKE CONGENITAL-ANOMALIES EXPOSURE INFLUENCES FISH EMBRYOS CRUDE-OIL DEFECTS
英文摘要	National Natural Science Foundation of China [21177103]; Fundamental Research Funds for the Central Universities [2012121045]; Recent studies show that polycyclic aromatic hydrocarbons (PAHs) may be a candidate cause of developmental defects of the retina, but the mechanism is still unclear. We evaluated the mechanism(s) underlying PAH-induced retinal development defects due to exposure to environmental concentrations of Phenanthrene (Phe) in zebrafish. We found that exposure to environmental concentrations of Phe caused obvious morphological changes, developmental retardation, apoptosis, and reduction of cell proliferation in the retina. Our results indicated that Phe could cause visual system developmental defects. Phe exposure up-regulated aryl hydrocarbon receptor (AhR) and microphthalmia-associated transcription factor (Mtif) expression, and down-regulated zinc finger E-box binding homeobox 1 (Zeb1) and paired box 6 (Pax6). Moreover, we demonstrated that AhR was a repressor of Zeb1. We propose that Phe's ocular toxicity is mediated by up-regulating AhR, which then down-regulates Zeb1, in turn inducing Mitf expression while inhibiting Pax6 expression. (C) 2013 Elsevier B.V. All rights reserved.
语种	英语
出版者	ELSEVIER SCIENCE BV
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/90669]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Huang, Lixing,Wang, Chonggang,Zhang, Youyu,et al. Phenanthrene causes ocular developmental toxicity in zebrafish embryos and the possible mechanisms involved[J]. http://dx.doi.org/10.1016/j.jhazmat.2013.07.030,2013.
APA	Huang, Lixing.,Wang, Chonggang.,Zhang, Youyu.,Wu, Meifang.,Zuo, Zhenghong.,...&左正宏.(2013).Phenanthrene causes ocular developmental toxicity in zebrafish embryos and the possible mechanisms involved.http://dx.doi.org/10.1016/j.jhazmat.2013.07.030.
MLA	Huang, Lixing,et al."Phenanthrene causes ocular developmental toxicity in zebrafish embryos and the possible mechanisms involved".http://dx.doi.org/10.1016/j.jhazmat.2013.07.030 (2013).