NMI mediates transcription-independent ARF regulation in response to cellular stresses

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	NMI mediates transcription-independent ARF regulation in response to cellular stresses
	Li, Zengpeng ; Hou, Jingjing ; Sun, Li ; Wen, Taoyong ; Wang, Liqin ; Zhao, Xinmeng ; Xie, Qingqing ; Zhang, Si Qing ; Zhang SQ(张四清) ; Li ZP(李增鹏) ; Hou JJ(侯静静)
刊名	http://dx.doi.org/10.1091/mbc.E12-04-0304
	2012-12-01
关键词	TUMOR-SUPPRESSOR ARF DNA-DAMAGE P53-DEPENDENT APOPTOSIS STABILIZES P53 HUMAN P14(ARF) BREAST-CANCER MDM2 MYC PROTEIN P19(ARF)
英文摘要	National Natural Science Foundation of China [30971489]; Natural Science Foundation of Fujian Province of China [2008J0111]; 973 program [2007CB914602]; Science Planning Program of Fujian Province [2009J1010]; 111 Project [B06016]; Program of Introducing Talents of Discipline to Universities [B12001]; The ARF tumor suppressor is a product of the INK4a/ARF locus, which is frequently mutated in human cancer. The expression of ARF is up-regulated in response to certain types of DNA damage, oncogene activation, and interferon stimuli. Through interaction with the p53 negative regulator MDM2, ARF controls a well-described p53/MDM2-dependent checkpoint. However, the mechanism of ARF induction is poorly understood. Using a yeast two-hybrid screen, we identify a novel ARF-interacting protein, N-Myc and STATs interactor (NMI). Previously, NMI was known to be a c-Myc-interacting protein. Here we demonstrate that through competitive binding to the ARF ubiquitin E3 ligase (ubiquitin ligase for ARF [ULF]), NMI protects ARF from ULF-mediated ubiquitin degradation. In response to cellular stresses, NMI is induced, and a fraction of NMI is translocated to the nucleus to stabilize ARF. Thus our work reveals a novel NMI-mediated, transcription-independent ARF induction pathway in response to cellular stresses.
语种	英语
出版者	MOL BIOL CELL
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/90582]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Li, Zengpeng,Hou, Jingjing,Sun, Li,et al. NMI mediates transcription-independent ARF regulation in response to cellular stresses[J]. http://dx.doi.org/10.1091/mbc.E12-04-0304,2012.
APA	Li, Zengpeng.,Hou, Jingjing.,Sun, Li.,Wen, Taoyong.,Wang, Liqin.,...&侯静静.(2012).NMI mediates transcription-independent ARF regulation in response to cellular stresses.http://dx.doi.org/10.1091/mbc.E12-04-0304.
MLA	Li, Zengpeng,et al."NMI mediates transcription-independent ARF regulation in response to cellular stresses".http://dx.doi.org/10.1091/mbc.E12-04-0304 (2012).