Ginsenoside Compound K Attenuates Metastatic Growth of Hepatocellular Carcinoma, which Is Associated with the Translocation of Nuclear Factor-kappa B p65 and Reduction of Matrix Metalloproteinase-2/9

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	Ginsenoside Compound K Attenuates Metastatic Growth of Hepatocellular Carcinoma, which Is Associated with the Translocation of Nuclear Factor-kappa B p65 and Reduction of Matrix Metalloproteinase-2/9
	Ming, Yanlin ; Chen, Zhongyan ; Chen, Lianghua ; Lin, Dejian ; Tong, Qingxuan ; Zheng, Zhizhong ; Song, Gang ; Song G(宋刚)
刊名	http://dx.doi.org/10.1055/s-0030-1250454
	2011-03
关键词	HUMAN HEPATOMA-CELLS INTESTINAL METABOLITE IN-VITRO CANCER SAPONIN ACTIVATION OSTEOPONTIN EXPRESSION APOPTOSIS BACTERIA
英文摘要	National Natural Science Foundation of China [31071187]; Research Institutes of the Fujian Province; Xiamen Municipal Science and Technology Innovation Fund [3502Z20062008]; The intestinal metabolite of ginseng saponin, compound K (CK), has various chemopreventive and chemotherapeutic activities, including antitumor activity. However, the functional mechanisms through which CK attenuates metastatic growth in hepatocellular carcinoma (HCC) remain unclear. Here, using multiple in vitro and in vivo models, we reported that CK strongly attenuated colony formation, adhesion, and invasion of HCC cells in vitro and dramatically inhibited spontaneous HCC metastatic growth in vivo. At the molecular level, immunofluorescence and Western blotting analysis confirmed that inhibition of metastatic growth of HCC induced by CK treatment caused a time-dependent decrease in nuclear NF-kappa B p65 and a concomitant increase in cytosolic NF-kappa B p65, indicating that CK suppressed the activation of the NF-kappa B pathway. Meanwhile, our study showed that the inhibition of matrix metalloproteinase2/9 (MMP2/9) expression caused by CK treatment was associated with NF-kappa B p65 nuclear export. Taken together, our results not only revealed that NF-kappa B p65 nuclear export and the reduction of MMP2/9 expression were associated with the metastatic inhibition induced by CK, but also suggested that CK may become a potential cytotoxic drug in the prevention and treatment of HCC.
语种	英语
出版者	PLANTA MED
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/90566]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Ming, Yanlin,Chen, Zhongyan,Chen, Lianghua,et al. Ginsenoside Compound K Attenuates Metastatic Growth of Hepatocellular Carcinoma, which Is Associated with the Translocation of Nuclear Factor-kappa B p65 and Reduction of Matrix Metalloproteinase-2/9[J]. http://dx.doi.org/10.1055/s-0030-1250454,2011.
APA	Ming, Yanlin.,Chen, Zhongyan.,Chen, Lianghua.,Lin, Dejian.,Tong, Qingxuan.,...&宋刚.(2011).Ginsenoside Compound K Attenuates Metastatic Growth of Hepatocellular Carcinoma, which Is Associated with the Translocation of Nuclear Factor-kappa B p65 and Reduction of Matrix Metalloproteinase-2/9.http://dx.doi.org/10.1055/s-0030-1250454.
MLA	Ming, Yanlin,et al."Ginsenoside Compound K Attenuates Metastatic Growth of Hepatocellular Carcinoma, which Is Associated with the Translocation of Nuclear Factor-kappa B p65 and Reduction of Matrix Metalloproteinase-2/9".http://dx.doi.org/10.1055/s-0030-1250454 (2011).