SIRT1 and p53, effect on cancer, senescence and beyond

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	SIRT1 and p53, effect on cancer, senescence and beyond
	Yi, Jingjie ; Luo, Jianyuan ; Yi JJ(易婧杰)
刊名	http://dx.doi.org/10.1016/j.bbapap.2010.05.002
	2010-08
关键词	TUMOR-SUPPRESSOR GENE DEPENDENT HISTONE DEACETYLASE EMBRYONIC STEM-CELLS DNA-DAMAGE RESPONSE REGULATES APOPTOSIS SIR2-ALPHA PROTEIN LIFE-SPAN ACETYLATION EXPRESSION ACTIVATION
英文摘要	China Scholarship Council; NIH/NIA; NAD(+)-dependent Class III histone deacetylase SIRT1 is a multiple function protein critically involved in stress responses, cellular metabolism and aging through deacetylating a variety of substrates including p53, forkhead-box transcription factors, PGC-1 alpha, NF-kappa B, Ku70 and histones. The first discovered non-histone target of SIRT1, p53, is suggested to play a central role in SIRT1-mediated functions in tumorigenesis and senescence. SIRT1 was originally considered to be a potential tumor promoter since it negatively regulates the tumor suppressor p53 and other tumor suppressors. There is new evidence that SIRT1 acts as a tumor suppressor based on its role in negatively regulating beta-catenin and survivin. This review provides an overview of current knowledge of SIRT1-p53 signaling and controversies regarding the functions of SIRT1 in tumorigenesis. (C) 2010 Elsevier B.V. All rights reserved.
语种	英语
出版者	BBA-PROTEINS PROTEOM
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/90496]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Yi, Jingjie,Luo, Jianyuan,Yi JJ. SIRT1 and p53, effect on cancer, senescence and beyond[J]. http://dx.doi.org/10.1016/j.bbapap.2010.05.002,2010.
APA	Yi, Jingjie,Luo, Jianyuan,&易婧杰.(2010).SIRT1 and p53, effect on cancer, senescence and beyond.http://dx.doi.org/10.1016/j.bbapap.2010.05.002.
MLA	Yi, Jingjie,et al."SIRT1 and p53, effect on cancer, senescence and beyond".http://dx.doi.org/10.1016/j.bbapap.2010.05.002 (2010).