Regulation of TCF3 by Wnt-Dependent Phosphorylation during Vertebrate Axis Specification

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	Regulation of TCF3 by Wnt-Dependent Phosphorylation during Vertebrate Axis Specification
	Hikasa, Hiroki ; Ezan, Jerome ; Itoh, Keiji ; Li, Xiaotong ; Klymkowsky, Michael W. ; Sokol, Sergei Y. ; Li XT(李晓彤)
刊名	http://dx.doi.org/10.1016/j.devcel.2010.09.005
	2010-10-19
关键词	INTERACTING PROTEIN KINASE-2 XENOPUS-LAEVIS EMBRYOS CELL SELF-RENEWAL NEMO-LIKE-KINASE BETA-CATENIN HOMEOBOX GENE C-ELEGANS SIGNALING PATHWAYS CAENORHABDITIS-ELEGANS MEDIATED TRANSCRIPTION
英文摘要	NIH; A commonly accepted model of Wnt/beta-catenin signaling involves target gene activation by a complex of beta-catenin with a T-cell factor (TCF) family member. TCF3 is a transcriptional repressor that has been implicated in Wnt signaling and plays key roles in embryonic axis specification and stem cell differentiation. Here we demonstrate that Wnt proteins stimulate TCF3 phosphorylation in gastrulating Xenopus embryos and mammalian cells. This phosphorylation event involves beta-catenin-mediated recruitment of homeodomain-interacting protein kinase 2 (HIPK2) to TCF3 and culminates in the dissociation of TCF3 from a target gene promoter. Mutated TCF3 proteins resistant to Wnt-dependent phosphorylation function as constitutive inhibitors of Wnt-mediated activation of Vent2 and Cdx4 during anteroposterior axis specification. These findings reveal an alternative in vivo mechanism of Wnt signaling that involves TCF3 phosphorylation and subsequent derepression of target genes and link this molecular event to a specific developmental process.
语种	英语
出版者	DEV CELL
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/90488]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Hikasa, Hiroki,Ezan, Jerome,Itoh, Keiji,et al. Regulation of TCF3 by Wnt-Dependent Phosphorylation during Vertebrate Axis Specification[J]. http://dx.doi.org/10.1016/j.devcel.2010.09.005,2010.
APA	Hikasa, Hiroki.,Ezan, Jerome.,Itoh, Keiji.,Li, Xiaotong.,Klymkowsky, Michael W..,...&李晓彤.(2010).Regulation of TCF3 by Wnt-Dependent Phosphorylation during Vertebrate Axis Specification.http://dx.doi.org/10.1016/j.devcel.2010.09.005.
MLA	Hikasa, Hiroki,et al."Regulation of TCF3 by Wnt-Dependent Phosphorylation during Vertebrate Axis Specification".http://dx.doi.org/10.1016/j.devcel.2010.09.005 (2010).