Novel cancerization marker, TP53, and its role in distinguishing normal tissue adjacent to cancerous tissue from normal tissue adjacent to benign tissue

CORC > 厦门大学 > 生命科学－已发表论文

	Novel cancerization marker, TP53, and its role in distinguishing normal tissue adjacent to cancerous tissue from normal tissue adjacent to benign tissue
	Liu, Guo-Yan ; Liu, Kun-Hong ; Li, Yin ; Pan, Chao ; Su, Ji-Qin ; Liao, Hong-Feng ; Yv, Ren-Xiang ; Li, Zhao-Hui ; Yuan, Li ; Zhang, Huan-Jing ; Tzeng, Chi-Meng ; Xiong, Bing ; Yuan L(袁立)
刊名	http://dx.doi.org/10.1186/1477-7819-10-252
	2012-11-21
关键词	EPITHELIAL-MESENCHYMAL TRANSITION FIELD CANCERIZATION TUMOR-MICROENVIRONMENT GENE-EXPRESSION BREAST-CANCER P53 MUTATIONS METASTASIS CARCINOMA INSIGHTS
英文摘要	Foundation of Xiamen Science and Technology Bureau [3502Z20104032, 3502Z20100002]; Medical innovation Foundation of Fujian Health Department [2011-CXB-38]; Natural Science Foundation of Fujian Province [2010J05137, 2012J01414]; National Natural Science Foundation of China [81272445, 61100106]; Background: The histopathological and molecular heterogeneity of normal tissue adjacent to cancerous tissue (NTAC) and normal tissue adjacent to benign tissue (NTAB), and the availability of limited specimens make deciphering the mechanisms of carcinogenesis challenging. Our goal was to identify histogenetic biomarkers that could be reliably used to define a transforming fingerprint using RNA in situ hybridization. Methods: We evaluated 15 tumor-related RNA in situ hybridization biomarkers using tumor microarray and samples of seven tumor-adjacent normal tissues from 314 patients. Biomarkers were determined using comprehensive statistical methods (significance of support vector machine-based artificial intelligence and area under curve scoring of classification distribution). Results: TP53 was found to be a most reliable index (P < 10(-7); area under curve >87%) for distinguishing NTAC from NTAB, according to the results of a significance panel (BCL10, BECN1, BRCA2, FITH, PTCH11 and TP53). Conclusions: The genetic alterations in TP53 between NTAC and NTAB may provide new insight into the field of cancerization and tumor transformation.
语种	英语
出版者	WORLD J SURG ONCOL
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/90461]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Liu, Guo-Yan,Liu, Kun-Hong,Li, Yin,et al. Novel cancerization marker, TP53, and its role in distinguishing normal tissue adjacent to cancerous tissue from normal tissue adjacent to benign tissue[J]. http://dx.doi.org/10.1186/1477-7819-10-252,2012.
APA	Liu, Guo-Yan.,Liu, Kun-Hong.,Li, Yin.,Pan, Chao.,Su, Ji-Qin.,...&袁立.(2012).Novel cancerization marker, TP53, and its role in distinguishing normal tissue adjacent to cancerous tissue from normal tissue adjacent to benign tissue.http://dx.doi.org/10.1186/1477-7819-10-252.
MLA	Liu, Guo-Yan,et al."Novel cancerization marker, TP53, and its role in distinguishing normal tissue adjacent to cancerous tissue from normal tissue adjacent to benign tissue".http://dx.doi.org/10.1186/1477-7819-10-252 (2012).