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	Aplysia mollusk-derived growth factor is a mitogen with adenosine deaminase activity and is expressed in the developing central nervous system
	Akalal, D. B. G. ; Bottenstein, J. E. ; Lee, S. H. ; Han, J. H. ; Chang, D. J. ; Kaang, B. K. ; Nagle, G. T. ; Han JH(韩家淮)
	2003
关键词	ADA adenosine deaminase-related growth factor Aplysia developing central nervous system insect-derived growth factor MDGF CECR1
英文摘要	Mollusk-derived growth factor (MDGF), the first growth factor to be characterized in Aplysia, was purified and characterized and has both adenosine deaminase activity and stimulates cell proliferation in vitro. MDGF is structurally related to a new subfamily of adenosine deaminase-related growth factors that require enzymatic activity to stimulate cell proliferation, a unique property of known growth factors. We examined the expression of MDGF protein in the CNS since MDGF mRNA increased in the developing CNS, and recent data suggest that inosine is involved in neuronal reorganization and restoration of essential circuitry after CNS injury. MDGF levels transiently increased during embryonic and post-metamorphic development and in the developing CNS, but was undetectable in adult CNS. No effects on morphology or neurite extension of adult Aplysia neurons were observed. (C) 2003 Elsevier B.V. All rights reserved.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/65886]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Akalal, D. B. G.,Bottenstein, J. E.,Lee, S. H.,et al. Aplysia mollusk-derived growth factor is a mitogen with adenosine deaminase activity and is expressed in the developing central nervous system[J],2003.
APA	Akalal, D. B. G..,Bottenstein, J. E..,Lee, S. H..,Han, J. H..,Chang, D. J..,...&韩家淮.(2003).Aplysia mollusk-derived growth factor is a mitogen with adenosine deaminase activity and is expressed in the developing central nervous system..
MLA	Akalal, D. B. G.,et al."Aplysia mollusk-derived growth factor is a mitogen with adenosine deaminase activity and is expressed in the developing central nervous system".(2003).

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