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	The p38 MAP kinase pathway and its biological function
	New, L. G. ; Han, J. H. ; Han JH(韩家淮)
	1998
关键词	ACTIVATED-PROTEIN-KINASE SIGNAL-TRANSDUCTION PATHWAY TUMOR-NECROSIS-FACTOR BACTERIAL LIPOPOLYSACCHARIDE TRANSCRIPTION FACTOR CELLULAR STRESSES TERMINAL KINASE FISSION YEAST CHOP GADD153 PHOSPHORYLATION
英文摘要	p38 is a mitogen-activated protein (MAP) kinase with structural and functional characteristics that distinguish it from JNK and ERK MAP kinases. p38 activity is upregulated when cells are exposed to a variety of stimuli including bacterial pathogens, proinflammatory cytokines, certain growth factors, and other forms of environmental stress. By regulating downstream substrates that include protein kinases and transcription factors, p38 participates in transmission, amplification, and diversification of the extracellular signal, initiating several different cellular responses. Studies have revealed that activation of p38 pathway is related tot many pathological changes that occur in the course of inflammatory/immunologic and cardiovascular diseases. (C) 1998, Elsevier Science Inc.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/65859]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	New, L. G.,Han, J. H.,Han JH. The p38 MAP kinase pathway and its biological function[J],1998.
APA	New, L. G.,Han, J. H.,&韩家淮.(1998).The p38 MAP kinase pathway and its biological function..
MLA	New, L. G.,et al."The p38 MAP kinase pathway and its biological function".(1998).

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