New components of the necroptotic pathway

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	New components of the necroptotic pathway
	Zhou, Zhenru ; Han, Victor ; Han, Jiahuai ; Han JH(韩家淮)
刊名	http://dx.doi.org/10.1007/s13238-012-2083-9
	2012-11
关键词	TUMOR-NECROSIS-FACTOR MIXED LINEAGE KINASE TNF-INDUCED NECROSIS CELL-DEATH PROGRAMMED NECROSIS MITOCHONDRIAL FISSION SIGNALING COMPLEX PERMEABILITY TRANSITION PROTECTS MICE CYTOCHROME-C
英文摘要	National Basic Research Program (973 Program) [2009CB522200]; National Natural Science Foundation of China [91029304, 30830092, 30921005, 81061160512]; 111 Project [B12001]; Programmed necrosis, also known as necroptosis, has recently drawn great attention. As an important cellular regulation mechanism, knowledge of its signaling components is expanding. Necroptosisis demonstrated to be regulated by the RIP1 and RIP3 kinases, and its pathophysiological importance has been confirmed in a number of disease models. Here we review the new members of this necroptosis pathway, MLKL, PGAM5, Drp1 and DAI, and discuss some of their possible applications according to recent findings.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/65858]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Zhou, Zhenru,Han, Victor,Han, Jiahuai,et al. New components of the necroptotic pathway[J]. http://dx.doi.org/10.1007/s13238-012-2083-9,2012.
APA	Zhou, Zhenru,Han, Victor,Han, Jiahuai,&韩家淮.(2012).New components of the necroptotic pathway.http://dx.doi.org/10.1007/s13238-012-2083-9.
MLA	Zhou, Zhenru,et al."New components of the necroptotic pathway".http://dx.doi.org/10.1007/s13238-012-2083-9 (2012).