MAPK signaling in inflammation-associated cancer development

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	MAPK signaling in inflammation-associated cancer development
	Huang, Pengyu ; Han, Jiahuai ; Hui, Lijian ; Han JH(韩家淮)
刊名	http://dx.doi.org/10.1007/s13238-010-0019-9
	2010-03
英文摘要	Shanghai Pujiang Program [09PJ1411200]; Knowledge Innovation Program of Shanghai Institutes for Biological Sciences [2009KIP101]; Knowledge Innovation Program of the Chinese Academy of Sciences [KSCX2-YW-R-241]; Chinese 973 program [2009CB522200]; Chinese; Mitogen-activated protein (MAP) kinases comprise a family of protein-serine/threonine kinases, which are highly conserved in protein structures from unicellular eukaryotic organisms to multicellular organisms, including mammals. These kinases, including ERKs, JNKs and p38s, are regulated by a phosphorelay cascade, with a prototype of three protein kinases that sequentially phosphorylate one another. MAPKs transduce extracellular signals into a variety of cellular processes, such as cell proliferation, survival, death, and differentiation. Consistent with their essential cellular functions, MAPKs have been shown to play critical roles in embryonic development, adult tissue homeostasis and various pathologies. In this review, we discuss recent findings that reveal the profound impact of these pathways on chronic inflammation and, particularly, inflammation-associated cancer development.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/65855]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Huang, Pengyu,Han, Jiahuai,Hui, Lijian,et al. MAPK signaling in inflammation-associated cancer development[J]. http://dx.doi.org/10.1007/s13238-010-0019-9,2010.
APA	Huang, Pengyu,Han, Jiahuai,Hui, Lijian,&韩家淮.(2010).MAPK signaling in inflammation-associated cancer development.http://dx.doi.org/10.1007/s13238-010-0019-9.
MLA	Huang, Pengyu,et al."MAPK signaling in inflammation-associated cancer development".http://dx.doi.org/10.1007/s13238-010-0019-9 (2010).