QQ客服 官方微博 反馈留言

	p38 mitogen-activated protein kinase is involved in Fas ligand expression
	Hsu, S. C. ; Gavrilin, M. A. ; Tsai, M. H. ; Han, J. H. ; Lai, M. Z. ; Han JH(韩家淮)
	1999
关键词	NF-KAPPA-B ICE/CED-3 FAMILY PROTEASES STRESS-INDUCED APOPTOSIS TUMOR-NECROSIS-FACTOR T-CELL HYBRIDOMAS SIGNALING PATHWAY RESPONSE ELEMENT TERMINAL KINASE CAMP INHIBITION HEPATOMA-CELLS
英文摘要	p38 mitogen-activated protein kinase (MAPK) is activated by T cell receptor engagement. Here we showed that T cell receptor activated p38 alpha but not p38 delta, Inhibition of p38 alpha by the specific inhibitor SE 203580 prevented activation-induced cell death in T cells. SE 203580 had no effect on Fas-initiated apoptosis. Instead, SE 203580 preferentially inhibited activation-induced Fas ligand (FasL) expression. The inhibition on Fast expression by SE 203580 was correlated with the suppression on the Fast promoter activation. Overexpression of active MAPK kinase 3b, the activator of p38 MAPK, led to activation of Fast promoter and induction of Fast transcripts in T cells. Stress stimulation of T cells by anisomycin also induced Fast expression in a p38 MAPK-dependent manner, The induction of Fast expression in nonlymphoid cells such as 293T also required activation of p38 MAPK. Our results suggest that p38 MAPK is essential for FasL expression.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/65835]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Hsu, S. C.,Gavrilin, M. A.,Tsai, M. H.,et al. p38 mitogen-activated protein kinase is involved in Fas ligand expression[J],1999.
APA	Hsu, S. C.,Gavrilin, M. A.,Tsai, M. H.,Han, J. H.,Lai, M. Z.,&韩家淮.(1999).p38 mitogen-activated protein kinase is involved in Fas ligand expression..
MLA	Hsu, S. C.,et al."p38 mitogen-activated protein kinase is involved in Fas ligand expression".(1999).

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。