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	Urokinase plasminogen activator/urokinase-specific surface receptor expression and matrix invasion by breast cancer cells requires constitutive p38 alpha mitogen-activated protein kinase activity
	Huang, S. ; New, L. ; Pan, Z. X. ; Han, J. H. ; Nemerow, G. R. ; Han JH(韩家淮)
	2000
关键词	EPIDERMAL GROWTH-FACTOR N-TERMINAL KINASE MESSENGER-RNA POSTTRANSCRIPTIONAL REGULATION EXTRACELLULAR-MATRIX SIGNALING PATHWAY GENE-EXPRESSION TUMOR P38 PROMOTER
英文摘要	Overexpression of urokinase plasminogen activator (uPA) and its receptor (uPAR) has been well documented in a wide variety of tumor cells. In breast cancer, expression of uPA/uPAR is essential for tumor cell invasion and metastasis. However, the mechanism responsible for uPA/uPAR expression in cancer cells remains unclear. In the studies reported here, we show that endogenous p38 MAPK activity correlates web with breast carcinoma cell invasiveness. Treatment of highly invasive BT549 cells with a specific p38 MAPK inhibitor SB203580 diminished both uPA/uPAR mRNA and protein expression and abrogated the ability of these cells to invade matrigel, suggesting that p38 MAPK signaling pathway is involved in the regulation of uPA/uPAR expression and breast cancer cell invasion. We also demonstrated that SB203580-induced reduction in uPA/uPAR mRNA expression resulted from the destabilization of uPA and uPAR mRNA. Finally, by selectively inhibiting p38 alpha or p38 beta MAPK isoforms, we demonstrate that p38 alpha, rather than paspl p38 beta, MAPK activity is essential for uPA/uPAR expression. These studies suggest that p38 alpha MAPK signaling pathway is important for the maintenance of breast cancer invasive phenotype by promoting the stabilities of uPA and uPAR mRNA.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/65831]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Huang, S.,New, L.,Pan, Z. X.,et al. Urokinase plasminogen activator/urokinase-specific surface receptor expression and matrix invasion by breast cancer cells requires constitutive p38 alpha mitogen-activated protein kinase activity[J],2000.
APA	Huang, S.,New, L.,Pan, Z. X.,Han, J. H.,Nemerow, G. R.,&韩家淮.(2000).Urokinase plasminogen activator/urokinase-specific surface receptor expression and matrix invasion by breast cancer cells requires constitutive p38 alpha mitogen-activated protein kinase activity..
MLA	Huang, S.,et al."Urokinase plasminogen activator/urokinase-specific surface receptor expression and matrix invasion by breast cancer cells requires constitutive p38 alpha mitogen-activated protein kinase activity".(2000).

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