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	Estrogen receptor inhibits c-Jun-dependent stress-induced cell death by binding and modifying c-Jun activity in human breast cancer cells
	Qi, X. M. ; Borowicz, S. ; Pramanik, R. ; Schultz, R. M. ; Han, J. H. ; Chen, G. ; Han JH(韩家淮)
	2004
关键词	ACTIVATED PROTEIN-KINASE D1 GENE-EXPRESSION SIGNAL-TRANSDUCTION CODING SEQUENCE AP-1 ACTIVITY APOPTOSIS PATHWAY GROWTH DNA P38
英文摘要	c-Jun, a major component of the AP-1 transcription factor, is either pro- or anti-apoptotic with cellular determinants unknown. Nuclear estrogen receptor (ER), on the other hand, regulates gene expression through both estrogen response elements and AP-1. Here we show that stress stimulates c-Jun phosphorylation and AP-1 activity in both ER+ and ER- human breast cancer cells and only induces cell death in ER- cells, indicating a determinant role of ER in c-Jun/AP-1 activity. The inhibitory effect of ER in stress-induced cell death is confirmed by ER transfection into ER- cells. Furthermore, inhibition of c-Jun activation by a dominant negative c-Jun blocks AP-1 activity in ER+ cells and attenuates stress-induced cell death but not AP-1 activity in ER- cells, suggesting that the c-Jun/AP-1 activity has distinct properties depending on ER status. ER was shown to inhibit stress-induced cell death through its physical interaction with c-Jun. This is because ER binds c-Jun in breast cancer cells, stress treatment further increases the ER-bound phosphorylated c-Jun, and the c-Jun binding-deficient ER mutant fails to protect stress-induced cell death. Together, our studies reveal a novel function of ER in stress response by modification of c-Jun activity.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/65805]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Qi, X. M.,Borowicz, S.,Pramanik, R.,et al. Estrogen receptor inhibits c-Jun-dependent stress-induced cell death by binding and modifying c-Jun activity in human breast cancer cells[J],2004.
APA	Qi, X. M..,Borowicz, S..,Pramanik, R..,Schultz, R. M..,Han, J. H..,...&韩家淮.(2004).Estrogen receptor inhibits c-Jun-dependent stress-induced cell death by binding and modifying c-Jun activity in human breast cancer cells..
MLA	Qi, X. M.,et al."Estrogen receptor inhibits c-Jun-dependent stress-induced cell death by binding and modifying c-Jun activity in human breast cancer cells".(2004).

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