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	Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-jun NH2-terminal kinase in ventricular muscle cells
	Wang, Y. B. ; Su, B. ; Sah, V. P. ; Brown, J. H. ; Han, J. H. ; Chien, K. R. ; Han JH(韩家淮)
	1998
关键词	GENE-EXPRESSION STIMULATION GROWTH
英文摘要	Activation of stress-activated protein kinases, including the p38 and the c-Jun NH2-terminal kinases (JNK), have been associated with the onset of cardiac hypertrophy and cell death in response to hemodynamic overload and ischemia/reperfusion injury. Upon infection of cultured neonatal rat cardiac myocytes with recombinant adenoviral vectors expressing a wild type and a constitutively active mutant of MKK7 (or JNKK2), JNK was specifically activated without affecting other mitogen-activated protein kinases, including extracellular signal-regulated protein kinases and p38. Specific activation of the JNK pathway in cardiac myocytes induced characteristic features of hypertrophy, including an increase in cell size, elevated expression of atrial natriuretic factor, and induction of sarcomere organization. In contrast, co-activation of both JNK (by MKK7) and p38 (by MKK3 or MKK6) in cardiomyocytes led to an induction of cytopathic responses and suppression of hypertrophic responses. These data provide the first direct evidence that activation of JNK alone is sufficient to induce characteristic features of cardiac hypertrophy, thereby supporting an active role for the JNK pathway in the development of cardiac hypertrophy, The cytopathic response, as a result of co activation of both JNK and p38, may contribute to the loss of contractile function and viability of cardiomyocytes following hemodynamic overload and cardiac ischemia/reperfusion injury.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/65804]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Wang, Y. B.,Su, B.,Sah, V. P.,et al. Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-jun NH2-terminal kinase in ventricular muscle cells[J],1998.
APA	Wang, Y. B..,Su, B..,Sah, V. P..,Brown, J. H..,Han, J. H..,...&韩家淮.(1998).Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-jun NH2-terminal kinase in ventricular muscle cells..
MLA	Wang, Y. B.,et al."Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-jun NH2-terminal kinase in ventricular muscle cells".(1998).

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