Lysophosphatidic acid induces prostate cancer PC3 cell migration via activation of LPA(1), p42 and p38 alpha | |
Hao, F. ; Tan, M. ; Xu, X. ; Han, J. ; Miller, D. D. ; Tigyi, G. ; Cui, M. Z. ; Han JH(韩家淮) | |
2007 | |
关键词 | lysophosphatidic acid receptors cell migration protein kinases and prostate cancer cells |
英文摘要 | Prostate cancer cell migration is an essential event both in the progression of prostate cancer and in the steps leading to metastasis. We report here that lysophosphatidic acid (LPA), a potent bioactive phospholipid, induces prostate cancer PC3 cell migration via the activati on of the LPA, receptor, which is linked to a PTX-seiisitive activation mechanism of the mitogen-activated protein kinases (MAPK). Our results demonstrate that parallel activation of ERK1/2 and p38, but not JNK, is responsible for LPA-stiniulated PC3 cell migration. Furthermore, using small interfering RNA (siRNA) technology, and overexpressing dominant-negative mutants of p38 MAPK isotypes of alpha, beta, gamma and delta, we have identified that the activation of ERK2 (p42) and p38 alpha, but not of ERK1 and the other isoforms of p38 MAPK, is required for LPA-induced migration. Our study provides the first evidence for a functional role of p42 and p38 alpha in LPA-induced mammalian cell migration, and also demonstrates, for the first time, that the receptor LPA(1) mediates prostate cancer cell migration. The results of the present study suggest that LPA the receptor LPA(1), ERK2 and p38 alpha are important regulators for prostate cancer cell invasion and thus could play a significant role in the development of metastasis.(c) 2007 Elsevier B.V. All rights reserved. |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://dspace.xmu.edu.cn/handle/2288/65727] ![]() |
专题 | 生命科学-已发表论文 |
推荐引用方式 GB/T 7714 | Hao, F.,Tan, M.,Xu, X.,et al. Lysophosphatidic acid induces prostate cancer PC3 cell migration via activation of LPA(1), p42 and p38 alpha[J],2007. |
APA | Hao, F..,Tan, M..,Xu, X..,Han, J..,Miller, D. D..,...&韩家淮.(2007).Lysophosphatidic acid induces prostate cancer PC3 cell migration via activation of LPA(1), p42 and p38 alpha.. |
MLA | Hao, F.,et al."Lysophosphatidic acid induces prostate cancer PC3 cell migration via activation of LPA(1), p42 and p38 alpha".(2007). |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论