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	Distinct DNA methylation profiles in ovarian serous neoplasms and their implications in ovarian carcinogenesis
	Chen L(陈亮)
	2010
关键词	methylation ovarian carcinoma
英文摘要	OBJECTIVE: The purpose of this study was to analyze DNA methylation profiles among different types of ovarian serous neoplasm, which is a task that has not been performed. STUDY DESIGN: The Illumina beads array (Illumina Inc, San Diego, CA) was used to profile DNA methylation in enriched tumor cells that had been isolated from 75 benign and malignant serous tumor tissues and 6 tumor-associated stromal cell cultures. RESULTS: We found significantly fewer hypermethylated genes in high-grade serous carcinomas than in low-grade serous carcinoma and borderline tumors, which in turn had fewer hypermethylated genes than serous cystadenoma. Unsupervised analysis identified that serous cystadenoma, serous borderline tumor, and low-grade serous carcinomas tightly clustered together and were clearly different from high-grade serous carcinomas. We also performed supervised analysis to identify differentially methylated genes that may contribute to group separation. CONCLUSION: The findings support the view that low-grade and high-grade serous carcinomas are distinctly different with low-grade, but not high-grade, serous carcinomas that are related to serous borderline tumor and cystadenoma.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/65578]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Chen L. Distinct DNA methylation profiles in ovarian serous neoplasms and their implications in ovarian carcinogenesis[J],2010.
APA	陈亮.(2010).Distinct DNA methylation profiles in ovarian serous neoplasms and their implications in ovarian carcinogenesis..
MLA	陈亮."Distinct DNA methylation profiles in ovarian serous neoplasms and their implications in ovarian carcinogenesis".(2010).

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