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	Intracellular free calcium regulates the onset of the respiratory burst of human neutrophils activated by phorbol myristate acetate
	Hu, T. H. ; Bei, L. ; Qian, Z. M. ; Shen, X. ; Hu TH(胡天惠)
	1999
关键词	respiratory burst neutrophil intracellular calcium protein kinase C thapsigargin signal transduction
英文摘要	Thapsigargin was used to study the regulation of different static calcium level ([Ca2+](i)) on the respiratory burst of human neutrophils stimulated with phorbol myristate acetate (PMA). The result showed that the onset time of the respiratory burst was obviously reduced by elevation of static [Ca2+](i) but is still much longer than that stimulated with N-formylmethionylleucylphenylalanine (fMLP). To find the reason, the onset times of the respiratory burst stimulated with fMLP, 1,2-dioctanoyl-sn-glycerol (DiC8), and PMA were determined at different static [Ca2+](i). It turns out that although DiC8 was unable to induce the respiratory burst at low [Ca2+](i), the onset time of DiC8-stimulated response at high [Ca2+](i) was almost the same as that stimulated with fMLP. The study revealed that the fast onset of the fMLP-stimulated respiratory burst in comparison with PMA-stimulated response is not only due to the transient rise of [Ca2+](i), but is also due to the higher efficiency of diacylglycerol (DAG) in activating protein kinase c (PKC). The determining step in governing the onset of a respiratory burst is the activation of PKC. CELL SIGNAL 11;5:355-360, 1999. (C) 1999 Elsevier Science Inc.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/65455]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Hu, T. H.,Bei, L.,Qian, Z. M.,et al. Intracellular free calcium regulates the onset of the respiratory burst of human neutrophils activated by phorbol myristate acetate[J],1999.
APA	Hu, T. H.,Bei, L.,Qian, Z. M.,Shen, X.,&胡天惠.(1999).Intracellular free calcium regulates the onset of the respiratory burst of human neutrophils activated by phorbol myristate acetate..
MLA	Hu, T. H.,et al."Intracellular free calcium regulates the onset of the respiratory burst of human neutrophils activated by phorbol myristate acetate".(1999).

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