Tributyltin exposure causes lipotoxicity responses in the ovaries of rockfish, Sebastiscus marmoratus

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	Tributyltin exposure causes lipotoxicity responses in the ovaries of rockfish, Sebastiscus marmoratus
	Zhang, Jiliang ; Zuo, Zhenghong ; Xiong, Jianli ; Sun, Ping ; Chen, Yixin ; Wang, Chonggang ; Wang ZG(王重刚)
刊名	http://dx.doi.org/10.1016/j.chemosphere.2012.10.078
	2013-01
英文摘要	Tributyltin (TBT) is a well-studied endocrine disruptor in mollusks and fishes. Recently, TBT is also recognized as a metabolic disruptor. Since abnormal lipids metabolism can induce negative effects on reproduction, the present study was designed to investigate the effects of TBT on ovarian lipid accumulation and testosterone esterification in rockfish (Sebastiscus marmoratus). After exposure for 48d, there was a decrease of neutral lipid droplets in the ooplasm of ovaries. Exposure has also induced lipotoxicity responses in the ovaries, which shown as an increase of interstitial ectopic lipid accumulation and total lipids. The decrease of serum triiodothyronine and thyroxine concentrations might be responsible for the lipotoxicity responses. In addition, the percentage of testosterone in an esterified form was significantly decreased in the ovaries by TBT exposure, which might be a mechanism by which free testosterone levels increased. The accumulation of ectopic lipids and increase of free testosterone levels in the ovaries might impact ovarian functions and oocyte development in fish. These results strongly indicate that TBT exposure can influence reproductive functions of rockfish through lipotoxic mechanism.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/65405]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Zhang, Jiliang,Zuo, Zhenghong,Xiong, Jianli,et al. Tributyltin exposure causes lipotoxicity responses in the ovaries of rockfish, Sebastiscus marmoratus[J]. http://dx.doi.org/10.1016/j.chemosphere.2012.10.078,2013.
APA	Zhang, Jiliang.,Zuo, Zhenghong.,Xiong, Jianli.,Sun, Ping.,Chen, Yixin.,...&王重刚.(2013).Tributyltin exposure causes lipotoxicity responses in the ovaries of rockfish, Sebastiscus marmoratus.http://dx.doi.org/10.1016/j.chemosphere.2012.10.078.
MLA	Zhang, Jiliang,et al."Tributyltin exposure causes lipotoxicity responses in the ovaries of rockfish, Sebastiscus marmoratus".http://dx.doi.org/10.1016/j.chemosphere.2012.10.078 (2013).