| Frequency dependent prolongation of effective refractory period by a complex class III antiarrhythmic agent CPU-86017 | |
| Li, H. T. ; Wang, Y. Q. ; Dai, D. Z. ; Kong, R. Z. ; Wang YQ(王义权) | |
| 2001 | |
| 关键词 | CPU-86017 myocardium lorcainide dofetilide verapamil amiodarone antiarrhythmic agents papillary muscles |
| 英文摘要 | AIM: To compare the prolongation of the effective refractory period (ERP) of a novel complex Class III agent CPU-86017 with compounds blocking I-Na (lorcainide, Lor), I-K (dofetilide, Dof), I-Ca (verapamil, Ver) and a complex Class III multiple channel blocking agent (amiodarone, Ami) at different frequency levels. METHODS: The ERP of the guinea pig right papillary muscle and the anoxic left atrial muscle treated with high K+ at pH 6.6 - 6.8, in concentrations ranging 0.03 - 30 mu mol/L was compared at frequency levels ranging from 0.5 - 4.0 Hz. RESULTS: CPU-86017 showed a positive frequency dependence (PFD) with respect to ERP in the papillary muscles and a mild reverse frequency dependence(RFD) in the diseased atrium. The potency of ERP prolonging effect of various agents at 4.0 Hz was Dof > CPU-86017 > Ver > Ami > Lor, and Dof > CPU-86017 > Ami > Lor > Ver in the normal papillary and diseased atrial muscle, respectively. CONCLUSION: The profile and potency of prolonging the ERP by CPU 86017 is similar to Dof which blocks I-Kr in the diseased atrium, and to Ver which blocks I-Ca in guinea pig ventricle. |
| 语种 | 英语 |
| 内容类型 | 期刊论文 |
| 源URL | [http://dspace.xmu.edu.cn/handle/2288/65385]  |
| 专题 | 生命科学－已发表论文 |
| 推荐引用方式 GB/T 7714 | Li, H. T.,Wang, Y. Q.,Dai, D. Z.,et al. Frequency dependent prolongation of effective refractory period by a complex class III antiarrhythmic agent CPU-86017[J],2001. |
| APA | Li, H. T.,Wang, Y. Q.,Dai, D. Z.,Kong, R. Z.,&王义权.(2001).Frequency dependent prolongation of effective refractory period by a complex class III antiarrhythmic agent CPU-86017.. |
| MLA | Li, H. T.,et al."Frequency dependent prolongation of effective refractory period by a complex class III antiarrhythmic agent CPU-86017".(2001). |
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