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	MOLECULAR-BASIS OF THE LITTLE MOUSE PHENOTYPE AND IMPLICATIONS FOR CELL-TYPE-SPECIFIC GROWTH
	Lin, S. C. ; Lin, C. J. R. ; Gukovsky, I. ; Lusis, A. J. ; Sawchenko, P. E. ; Rosenfeld, M. G. ; Lin SC(林圣彩)
	1993
关键词	HORMONE-RELEASING-FACTOR ANTERIOR-PITUITARY CELLS PANCREATIC-ISLET TUMOR TRANSGENIC MICE MESSENGER-RNA DWARF MICE THYROID-CELLS CYCLIC-AMP PROTEIN GENE
英文摘要	The molecular basis for the little (lit) mouse phenotype, characterized by a hypoplastic anterior pituitary gland, is the mutation of a single nucleotide that alters Asp 60 to Gly in the growth hormone releasing factor receptor. Detailed analysis of the lit mouse anterior pituitary reveals spatially distinct proliferative zones of growth hormone-producing stem cells and mature somatotrophs, each regulated by a different trophic factor. This sequential growth factor requirement for a specific cell type may exemplify a common strategy for regulating cellular proliferation in other mammalian organs.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/65330]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Lin, S. C.,Lin, C. J. R.,Gukovsky, I.,et al. MOLECULAR-BASIS OF THE LITTLE MOUSE PHENOTYPE AND IMPLICATIONS FOR CELL-TYPE-SPECIFIC GROWTH[J],1993.
APA	Lin, S. C..,Lin, C. J. R..,Gukovsky, I..,Lusis, A. J..,Sawchenko, P. E..,...&林圣彩.(1993).MOLECULAR-BASIS OF THE LITTLE MOUSE PHENOTYPE AND IMPLICATIONS FOR CELL-TYPE-SPECIFIC GROWTH..
MLA	Lin, S. C.,et al."MOLECULAR-BASIS OF THE LITTLE MOUSE PHENOTYPE AND IMPLICATIONS FOR CELL-TYPE-SPECIFIC GROWTH".(1993).

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