QQ客服 官方微博 反馈留言

	Axin forms a complex with MEKK1 and activates c-Jun NH2-terminal kinase/stress-activated protein kinase through domains distinct from Wnt signaling
	Zhang, Y. ; Neo, S. Y. ; Wang, X. H. ; Han, J. H. ; Lin, S. C. ; Lin SC(林圣彩)
	1999
关键词	KAPPA-B ACTIVATION MOUSE FUSED LOCUS BETA-CATENIN FUNCTIONAL INTERACTION TRANSDUCTION PATHWAYS NEGATIVE REGULATOR XENOPUS EMBRYOS RGS PROTEINS TRANSCRIPTION APOPTOSIS
英文摘要	Axin negatively regulates the Wnt pathway during axis formation and plays a central role in cell growth control and tumorigenesis, We found that Axin also serves as a scaffold protein for mitogen-activated protein kinase activation and further determined the structural requirement for this activation. Overexpression of Axin in 293T cells leads to differential activation of mitogen-activated protein kinases, with robust induction for c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase, moderate induction for p38, and negligible induction for extracellular signal-regulated kinase, Axin forms a complex with MEKK1 through a novel domain that we term MEKK1-interacting domain, MKK4 and MKK7, which act do downstream of MEKK1, are also involved in Axin-mediated JNK activation. Domains essential in Wnt signaling, i.e, binding sites for adenomatous polyposis coli, glycogen synthase kinase-3 beta, and beta-catenin, are not required for JNK activation, suggesting distinct domain utilization between the Wnt pathway and JNK signal transduction. Dimerization/oligomerization of Axin through its C terminus is required for JNK activation, although MEKK1 is capable of binding C terminus-deleted monomeric Axin, Furthermore, Axin without the MEKK1-interacting domain has a dominant-negative effect on JNK activation by wild-type Axin, Our results suggest that Axin, in addition to its function in the Wnt pathway, may play a dual role in cells through its activation of JNK/stress-activated protein kinase signaling cascade.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/65308]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Zhang, Y.,Neo, S. Y.,Wang, X. H.,et al. Axin forms a complex with MEKK1 and activates c-Jun NH2-terminal kinase/stress-activated protein kinase through domains distinct from Wnt signaling[J],1999.
APA	Zhang, Y.,Neo, S. Y.,Wang, X. H.,Han, J. H.,Lin, S. C.,&林圣彩.(1999).Axin forms a complex with MEKK1 and activates c-Jun NH2-terminal kinase/stress-activated protein kinase through domains distinct from Wnt signaling..
MLA	Zhang, Y.,et al."Axin forms a complex with MEKK1 and activates c-Jun NH2-terminal kinase/stress-activated protein kinase through domains distinct from Wnt signaling".(1999).

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。