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	The ames dwarf gene is required for Pit-1 gene activation
	Andersen, B. ; Pearse, R. V. ; Jenne, K. ; Sornson, M. ; Lin, S. C. ; Bartke, A. ; Rosenfeld, M. G. ; Lin SC(林圣彩)
	1995
关键词	HORMONE DEFICIENCY GROWTH-HORMONE TRANSCRIPTION FACTORS TRANSGENIC MICE PITUITARY MUTATION DOMAIN SNELL
英文摘要	The tissue-specific POU domain transcription factor Pit-1 is required for phenotypic specification of three cell types in the anterior pituitary gland of mammals: somatotropes, thyrotropes, and lactotropes. Mutations in the Pit-1 gene, as first described in Snell and Jackson dwarf (dw) mice, led to pituitary hypoplasia due to lack of these three cell types, as well as hypothyroidism and dwarfism because of deficiency of thyroid-stimulating hormone and growth hormone, respectively. The Ames dwarf (df) exhibits a phenotype identical to that of Pit-1-mutated mice but the defective gene has been mapped to a locus on mouse chromosome 11, distinct from the Pit-1 gene located on mouse chromosome 6. Our studies indicate that initial activation of the Pit-1 gene is deficient in the Ames dwarf. This suggests that the df gene is required for activation of the Pit-1 gene and provides evidence for a hierarchy of tissue-specific factors required for cellular commitment in the anterior pituitary gland. (C) 1995 Academic Press, Inc.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/65301]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Andersen, B.,Pearse, R. V.,Jenne, K.,et al. The ames dwarf gene is required for Pit-1 gene activation[J],1995.
APA	Andersen, B..,Pearse, R. V..,Jenne, K..,Sornson, M..,Lin, S. C..,...&林圣彩.(1995).The ames dwarf gene is required for Pit-1 gene activation..
MLA	Andersen, B.,et al."The ames dwarf gene is required for Pit-1 gene activation".(1995).

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