QQ客服 官方微博 反馈留言

	Multiple phosphorylation sites in RGS16 differentially modulate its GAP activity
	Chen, C. H. ; Wang, H. S. ; Fong, C. W. ; Lin, S. C. ; Lin SC(林圣彩)
	2001
关键词	regulators of G-protein signaling G protein phosphorylation alpha 2A adrenergic receptor epinephrine
英文摘要	Regulators of G-protein signaling (RGS) are GTPase-activating proteins (GAP) for activated G alpha subunits. We found that mouse RGS16, when expressed in HEK293T cells, is phosphorylated constitutively at serine 194 based on in vivo orthophosphate labeling experiments, while serine 53 is phosphorylated in a ligand-dependent manner upon stimulation by epinephrine in cells expressing the alpha 2A adrenergic receptor. Phosphorylation on both sites impairs its GAP activity and subsequent attenuation on heterotrimeric G-protein-stimulated extracellular signal-regulated protein kinase activity. This is the first report of RGS functional downregulation by phosphorylation via a G-protein-coupled receptor. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/65297]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Chen, C. H.,Wang, H. S.,Fong, C. W.,et al. Multiple phosphorylation sites in RGS16 differentially modulate its GAP activity[J],2001.
APA	Chen, C. H.,Wang, H. S.,Fong, C. W.,Lin, S. C.,&林圣彩.(2001).Multiple phosphorylation sites in RGS16 differentially modulate its GAP activity..
MLA	Chen, C. H.,et al."Multiple phosphorylation sites in RGS16 differentially modulate its GAP activity".(2001).

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。