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	Basigin expression and hormonal regulation in mouse uterus during the peri-implantation period
	Xiao, L. J. ; Chang, H. ; Ding, N. Z. ; Ni, H. ; Kadomatsu, K. ; Yang, Z. M. ; Yang ZM(杨增明)
	2002
关键词	basigin decidua uterus implantation mouse
英文摘要	Basigin, a transmembrane glycoprotein belonging to the immunoglobulin superfamily, has been shown to be essential for fertilization and implantation. The aim of this study was to determine the expression and hormonal regulation of basigin gene in mouse uterus during the peri-implantation period. Basigin immunostaining and mRNA were strongly localized in luminal and glandular epithelium on day 1 of pregnancy and gradually decreased to a basal level from day 2-4 of pregnancy. Basigin mRNA expression in the sub-luminal stroma was first detected on day 3 of pregnancy and increased on day 4 of pregnancy. On day 5 of pregnancy, the expression of basigin protein and mRNA was only detected in the implanting embryos, and the luminal epithelium and sub-luminal stroma surrounding the embryos. A similar expression pattern of basigin was also induced in the delayed-implantation uterus which was activated by estrogen injection. On day 6-8 of pregnancy, although a basal level of basigin protein was detected in the secondary decidual zone, basigin mRNA expression was strongly seen in this location. Basigin mRNA was also highly expressed in the decidualized cells under artificial decidualization. Estrogen significantly stimulated basigin expression in the ovariectomized mouse uterus. A high level of basigin immunostaining and mRNA was also seen in proestrus and estrus uteri. These results suggest that basigin expression is closely related to mouse implantation and up-regulated by estrogen. Mol. Reprod, Dev. 63: 47-54, 2002, (C) 2002 Wiley-Liss, Inc.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/65245]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Xiao, L. J.,Chang, H.,Ding, N. Z.,et al. Basigin expression and hormonal regulation in mouse uterus during the peri-implantation period[J],2002.
APA	Xiao, L. J..,Chang, H..,Ding, N. Z..,Ni, H..,Kadomatsu, K..,...&杨增明.(2002).Basigin expression and hormonal regulation in mouse uterus during the peri-implantation period..
MLA	Xiao, L. J.,et al."Basigin expression and hormonal regulation in mouse uterus during the peri-implantation period".(2002).

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