Differential hormonal regulation of leukemia inhibitory factor (LIF) in rabbit and mouse uterus | |
Yang, Z. M. ; Chen, D. B. ; Le, S. P. ; Harper, M. J. K. ; Yang ZM(杨增明) | |
1996 | |
关键词 | leukemia inhibitory factor rabbit mouse hormonal regulation endometrium |
英文摘要 | Leukemia inhibitory factor (LIF) has been shown to be essential for the implantation of mouse blastocysts. The present study was designed to determine how LIF protein was hormonally regulated in rabbit and mouse uterus using immunohistochemistry. in unmated rabbits, LIF protein was at a low level in the uterine epithelium and glands, and up-regulated by progesterone alone or estradiol-17 beta and progesterone combined. Estradiol-17 beta alone had no apparent effect. In ovariectomized mice, the level of LIF protein was very low in the uterine epithelium and glands, and was up-regulated by estradiol-17 beta alone or estradiol-17 beta and progesterone combined. Progesterone alone had no apparent effect. These results suggest that LIF protein is differentially regulated in rabbit and mouse uterus by progesterone and estrogen, respectively. This would explain the high level of LIF protein observed in uterine epithelium and glands prior to blastocyst implantation in the two species with different hormonal requirements for implantation. (C) 1996 Wiley-Liss, Inc. |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://dspace.xmu.edu.cn/handle/2288/65242] ![]() |
专题 | 生命科学-已发表论文 |
推荐引用方式 GB/T 7714 | Yang, Z. M.,Chen, D. B.,Le, S. P.,et al. Differential hormonal regulation of leukemia inhibitory factor (LIF) in rabbit and mouse uterus[J],1996. |
APA | Yang, Z. M.,Chen, D. B.,Le, S. P.,Harper, M. J. K.,&杨增明.(1996).Differential hormonal regulation of leukemia inhibitory factor (LIF) in rabbit and mouse uterus.. |
MLA | Yang, Z. M.,et al."Differential hormonal regulation of leukemia inhibitory factor (LIF) in rabbit and mouse uterus".(1996). |
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