Junctional Adhesion Molecule 2 Mediates the Interaction between Hatched Blastocyst and Luminal Epithelium: Induction by Progesterone and LIF

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	Junctional Adhesion Molecule 2 Mediates the Interaction between Hatched Blastocyst and Luminal Epithelium: Induction by Progesterone and LIF
	Su, Ren-Wei ; Jia, Bo ; Ni, Hua ; Lei, Wei ; Yue, Shun-Li ; Feng, Xu-Hui ; Deng, Weng-Bo ; Liu, Ji-Long ; Zhao, Zhen-Ao ; Wang, Tong-Song ; Yang, Zeng-Ming ; Yang ZM(杨增明)
刊名	http://dx.doi.org/10.1371/journal.pone.0034325
	2012-04-12
关键词	LEUKEMIA INHIBITORY FACTOR HEMATOPOIETIC STEM-CELLS MOUSE UTERUS EMBRYO IMPLANTATION DIFFERENTIAL EXPRESSION GENE-EXPRESSION JAM-B STAT3 PERIIMPLANTATION ALPHA-4-BETA-1
英文摘要	National Basic Research Program of China [2011CB944402]; National Natural Science Foundation of China [30930013, 31071276]; Background: Junctional adhesion molecule 2 (Jam2) is a member of the JAM superfamily. JAMs are localized at intercellular contacts and participated in the assembly and maintenance of junctions, and control of cell permeability. Because Jam2 is highly expressed in the luminal epithelium on day 4 of pregnancy, this study was to determine whether Jam2 plays a role in uterine receptivity and blastocyst attachment in mouse uterus. Methodology/Principal Findings: Jam2 is highly expressed in the uterine luminal epithelium on days 3 and 4 of pregnancy. Progesterone induces Jam2 expression in ovariectomized mice, which is blocked by progesterone antagonist RU486. Jam2 expression on day 4 of pregnancy is also inhibited by RU486 treatment. Leukemia inhibitory factor (LIF) up-regulates Jam2 protein in isolated luminal epithelium from day 4 uterus, which is blocked by S3I-201, a cell-permeable inhibitor for Stat3 phosphorylation. Under adhesion assay, recombinant Jam2 protein increases the rate of blastocyst adhesion. Both soluble recombinant Jam2 and Jam3 can reverse this process. Conclusion: Jam2 is highly expressed in the luminal epithelium of receptive uterus and up-regulated by progesterone and LIF via tyrosine phosphorylation of Stat3. Jam2 may play a role in the interaction between hatched blastocyst and receptive uterus.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/65236]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Su, Ren-Wei,Jia, Bo,Ni, Hua,et al. Junctional Adhesion Molecule 2 Mediates the Interaction between Hatched Blastocyst and Luminal Epithelium: Induction by Progesterone and LIF[J]. http://dx.doi.org/10.1371/journal.pone.0034325,2012.
APA	Su, Ren-Wei.,Jia, Bo.,Ni, Hua.,Lei, Wei.,Yue, Shun-Li.,...&杨增明.(2012).Junctional Adhesion Molecule 2 Mediates the Interaction between Hatched Blastocyst and Luminal Epithelium: Induction by Progesterone and LIF.http://dx.doi.org/10.1371/journal.pone.0034325.
MLA	Su, Ren-Wei,et al."Junctional Adhesion Molecule 2 Mediates the Interaction between Hatched Blastocyst and Luminal Epithelium: Induction by Progesterone and LIF".http://dx.doi.org/10.1371/journal.pone.0034325 (2012).