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	Cyclooxygenases and prostaglandin E synthases in the endometrium of the rhesus monkey during the menstrual cycle
	Sun, T. ; Li, S. J. ; Diao, H. L. ; Teng, C. B. ; Wang, H. B. ; Yang, Z. M. ; Yang ZM(杨增明)
	2004
关键词	ENDOTHELIAL GROWTH-FACTOR EMBRYO IMPLANTATION MOUSE UTERUS DEVELOPMENTAL EXPRESSION PERIIMPLANTATION PERIOD E-2 BIOSYNTHESIS ESTROUS-CYCLE CELLS MICE IDENTIFICATION
英文摘要	Cyclooxygenase (COX), a rate-limiting enzyme that produces prostaglandins (PGs) from arachidonic acid, exists in two isoforms, COX-1 and COX-2. PGE2 synthase (PGES) is a terminal prostanoid synthase and can enzymatically convert the cyclooxygenase product PGH(2) to PGE(2), including two isoforms: microsomal PGES (mPGES) and cytosolic PGES (cPGES). cPGES is predominantly linked with COX-1 to promote the immediate response. mPGES is preferentially coupled with the inducible COX-2 to promote delayed PGE2 generation. COX-2-deficient female mice are infertile with abnormalities in ovulation, fertilization, implantation and decidualization. The aim of this study was to examine immunohistochemically the expression pattern of COX-1, COX-2, mPGES and cPGES proteins in the endometriurm of the rhesus monkey during the menstrual cycle. COX-1 immunostaining was mainly localized in the luminal epithelium and glandular epithelium near the lumen, and detected in all the stages during the menstrual cycle. COX-2 immunostaining was mainly localized in the luminal and glandular epithelium, and strongly shown during the mid-luteal phase (days 16 and 20) of the menstrual cycle. There was a strong cPGES immunostaining in the luminal and glandular epithelium on days 12, 16, 20 and 25 of the menstrual cycle. mPGES immunostaining was strongly detected in the glandular epithelium on days 20 and 25 of the menstrual cycle. These data suggest that the coupling of cPGES and COX-1 in the luminal epithelium may be responsible for the synthesis of PGE2 in monkey endometrium, and the coupling of mPGES and COX-2 in the glandular epithelium may be of importance for preparing the receptive endometrium.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/65231]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Sun, T.,Li, S. J.,Diao, H. L.,et al. Cyclooxygenases and prostaglandin E synthases in the endometrium of the rhesus monkey during the menstrual cycle[J],2004.
APA	Sun, T..,Li, S. J..,Diao, H. L..,Teng, C. B..,Wang, H. B..,...&杨增明.(2004).Cyclooxygenases and prostaglandin E synthases in the endometrium of the rhesus monkey during the menstrual cycle..
MLA	Sun, T.,et al."Cyclooxygenases and prostaglandin E synthases in the endometrium of the rhesus monkey during the menstrual cycle".(2004).

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