Localization and Altered Expression of Nucleophosmin in the Nuclear Matrix During the Differentiation of Human Hepatocarcinoma SMMC-7721 Cells Induced by HMBA

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	Localization and Altered Expression of Nucleophosmin in the Nuclear Matrix During the Differentiation of Human Hepatocarcinoma SMMC-7721 Cells Induced by HMBA
	Li, Q. F. ; Tang, J. A. ; Liu, Q. R. ; Shi, S. L. ; Chen, X. F. ; Li QF(李祺福)
刊名	http://dx.doi.org/10.3109/07357900902918452
	2010-12
关键词	TUMOR-SUPPRESSOR PROTEIN RETINOIC ACID PROSTATE-CANCER HL-60 CELLS HELA-CELLS APOPTOSIS NPM ACTIVATION PATHWAY B23
英文摘要	National Natural Science Foundation of China [30470877]; Nucleophosmin (NPM1) is frequently upregulated and mutated in various tumor cells. To investigate the mechanism of induced differentiation of tumor cells, the nuclear matrix of human hepatocarcinoma SMMC-7721 cells induced by hexamethylene bisacetamide (HMBA) was selectively extracted and subjected to proteomic methodologies. We confirmed that NPM1 existed in nuclear matrix proteins and downregulated after HMBA treatment. By using immunogold electromicroscopy, we found that NPM1 was localized on nuclear matrix-intermediate filaments. Our study also revealed the colocalization between NPM1 and products of oncogenes or tumor surppresor genes including c-Fos, c-Myc, p53, and Rb by using laser scanning confocal microscopy in SMMC-7721 cells.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/65174]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Li, Q. F.,Tang, J. A.,Liu, Q. R.,et al. Localization and Altered Expression of Nucleophosmin in the Nuclear Matrix During the Differentiation of Human Hepatocarcinoma SMMC-7721 Cells Induced by HMBA[J]. http://dx.doi.org/10.3109/07357900902918452,2010.
APA	Li, Q. F.,Tang, J. A.,Liu, Q. R.,Shi, S. L.,Chen, X. F.,&李祺福.(2010).Localization and Altered Expression of Nucleophosmin in the Nuclear Matrix During the Differentiation of Human Hepatocarcinoma SMMC-7721 Cells Induced by HMBA.http://dx.doi.org/10.3109/07357900902918452.
MLA	Li, Q. F.,et al."Localization and Altered Expression of Nucleophosmin in the Nuclear Matrix During the Differentiation of Human Hepatocarcinoma SMMC-7721 Cells Induced by HMBA".http://dx.doi.org/10.3109/07357900902918452 (2010).