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	AMP as a Low-Energy Charge Signal Autonomously Initiates Assembly of AXIN-AMPK-LKB1 Complex for AMPK Activation
	Ya-Lin Zhang ; Huiling Guo ; Chen-Song Zhang ; Shu-Yong Lin ; Lin SY(林舒勇) ; Zhenyu Yin ; Yongying Peng ; Hui Luo ; Yuzhe Shi ; Guili Lian ; Cixiong Zhang ; Mengqi Li ; Zhiyun Ye ; Ye ZY(叶志云) ; Jing Ye ; Ye J(叶菁) ; Jiahuai Han ; Han JH(韩家淮) ; Peng Li ; ia-Wei Wu ; Sheng-Cai Lin ; Lin SC(林圣彩)
	2013-10-01
英文摘要	The AMP-activated protein kinase (AMPK) is a master regulator of metabolic homeostasis by sensing cellular energy status. AMPK is mainly activated via phosphorylation by LKB1 when cellular AMP/ADP levels are increased. However, how AMP/ADP brings about AMPK phosphorylation remains unclear. Here, we show that it is AMP, but not ADP, that drives AXIN to directly tether LKB1 to phosphorylate AMPK. The complex formation of AXIN-AMPK-LKB1 is greatly enhanced in glucose-starved or AICAR-treated cells and in cell-free systems supplemented with exogenous AMP. Depletion of AXIN abrogated starvation-induced AMPK-LKB1 colocalization. Importantly, adenovirus-based knockdown of AXIN in the mouse liver impaired AMPK activation and caused exacerbated fatty liver after starvation, underscoring an essential role of AXIN in AMPK activation. These findings demonstrate an initiating role of AMP and demonstrate that AXIN directly transmits AMP binding of AMPK to its activation by LKB1, uncovering the mechanistic route for AMP to elicit AMPK activation by LKB1.; http://news.xmu.edu.cn/s/13/t/542/22/a9/info139945.htm
语种	英语
出版者	Cell Press
内容类型	期刊论文
源URL	[http://dx.doi.org/10.1016/j.cmet.2013.09.005]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Ya-Lin Zhang,Huiling Guo,Chen-Song Zhang,et al. AMP as a Low-Energy Charge Signal Autonomously Initiates Assembly of AXIN-AMPK-LKB1 Complex for AMPK Activation[J],2013.
APA	Ya-Lin Zhang.,Huiling Guo.,Chen-Song Zhang.,Shu-Yong Lin.,林舒勇.,...&林圣彩.(2013).AMP as a Low-Energy Charge Signal Autonomously Initiates Assembly of AXIN-AMPK-LKB1 Complex for AMPK Activation..
MLA	Ya-Lin Zhang,et al."AMP as a Low-Energy Charge Signal Autonomously Initiates Assembly of AXIN-AMPK-LKB1 Complex for AMPK Activation".(2013).

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