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	Benzo[a]pyrene exposure influences the cardiac development and the expression of cardiovascular relative genes in zebrafish (Danio rerio) embryos
	Huang, Lixing ; Wang, Chonggang ; Wang ZG(王重刚) ; Zhang, Youyu ; Li, Jian ; Zhong, Yuanfu ; Zhou, Yulin ; Chen, Yixin ; Chen YX(陈奕欣) ; Zuo, Zhenghong ; Zuo ZH(左正宏)
	2012-04
关键词	B(a)P Cardiac toxicity Embryonic development Gene regulatory networks Microarray Zebrafish
英文摘要	It is reported that the most abundant polycyclic aromatic hydrocarbons (PAHs) in weathered crude oils are cardiotoxic. However, the action mechanism of PAHs on vertebrate cardiovascular development and disease is unclear. In the present study, the cardiac morphology and functioning of zebrafish embryos exposed to benzo[a]pyrene [B(a)P], as a high-ring PAHs, for 72 h were observed and determined. The results showed that B(a)P exposure resulted in cardiac developmental defects in zebrafish embryos. Significant changes in expression level of multiple genes potentially critical for regulating the B(a)P-induced cardiovascular developmental defects were also found. A gene network regulating cardiac development perturbed by B(a)P exposure was identified and established by computational analysis and employment of some databases. The information from the network could provide a clue for further mechanistic studies explaining molecular events regulating B(a)P-mediated cardiovascular defects and consequences. (C) 2011 Elsevier Ltd. All rights reserved.; National Natural Science Foundation of China [20877064]; Natural Scientific Fund of Fujian Province, China [2009J01225]; program for Changjiang Scholars and Innovative Research Team in University [IRT0941]; National Foundation for fostering talents of basic science [J1030626]
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
内容类型	期刊论文
源URL	[http://dx.doi.org/10.1016/j.chemosphere.2011.12.026]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Huang, Lixing,Wang, Chonggang,Wang ZG,et al. Benzo[a]pyrene exposure influences the cardiac development and the expression of cardiovascular relative genes in zebrafish (Danio rerio) embryos[J],2012.
APA	Huang, Lixing.,Wang, Chonggang.,王重刚.,Zhang, Youyu.,Li, Jian.,...&左正宏.(2012).Benzo[a]pyrene exposure influences the cardiac development and the expression of cardiovascular relative genes in zebrafish (Danio rerio) embryos..
MLA	Huang, Lixing,et al."Benzo[a]pyrene exposure influences the cardiac development and the expression of cardiovascular relative genes in zebrafish (Danio rerio) embryos".(2012).

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