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	Macrophage migration inhibitory factor homolog from Plasmodium yoelii modulates monocyte recruitment and activation in spleen during infection
	Zhang, Yanhui ; Miura, Kazutoyo ; Li, Jian ; Tullo, Gregory ; Zhu, Feng ; Hong, Lingxian ; Hong LX(洪凌仙) ; Lin, Tianlong ; Su, Xin-zhuan ; Long, Carole
	2012-05
关键词	FACTOR MIF FALCIPARUM-MALARIA INDUCED ARTHRITIS EXPRESSION HEMOZOIN ANTIGEN ANEMIA CELLS GLUCOCORTICOIDS PHAGOCYTOSIS
英文摘要	Macrophage migration inhibitory factor (MIF) has been shown to be involved in the pathogenesis of severe malaria. Malaria parasites express an MIF homolog that may play a role in regulating host immune responses, and a recent study showed that overexpression of MIF reduced parasitemia in a mouse malaria model. Another recent study showed migration of monocytes to the spleen contributed to the control of blood stage infection. However, there are few papers describing the effect of MIF on monocyte recruitment/activation during the infection. We generated recombinant Plasmodium yoelii MIF (rPyMIF) and investigated its function on purified mouse CD11b(+) cells in vitro and monocyte responses in vivo. The result shows that rPyMIF protein bound to mouse CD11b(+) cells and inhibited their random migration in vitro. On the other hand, rPyMIF did not induce cytokine release from the cells directly or modulate lipopolysaccharide-induced cytokine release. Mice immunized with rPyMIF showed transient but significantly lower parasitemia than the control mice at day 3 after lethal Py17XL challenge. The total number of CD11b(+) cells in the spleens was significantly higher in rPyMIF-immunized group. Further investigation revealed that there were significantly higher numbers of recruited and activated monocytes in the spleens of rPyMIF immunization group on day 3. These results indicate that PyMIF potentially modulates monocyte recruitment and activation during infection of P. yoelii erythrocytic stages.; Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health; National Basic Research Program of China (973 Program) [2007CB513103]; Science Planning Program of Fujian Province [2010 J1008]; 111 Project of Education of China [B06016]
语种	英语
出版者	SPRINGER
内容类型	期刊论文
源URL	[http://dx.doi.org/10.1007/s00436-011-2696-6]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Zhang, Yanhui,Miura, Kazutoyo,Li, Jian,et al. Macrophage migration inhibitory factor homolog from Plasmodium yoelii modulates monocyte recruitment and activation in spleen during infection[J],2012.
APA	Zhang, Yanhui.,Miura, Kazutoyo.,Li, Jian.,Tullo, Gregory.,Zhu, Feng.,...&Long, Carole.(2012).Macrophage migration inhibitory factor homolog from Plasmodium yoelii modulates monocyte recruitment and activation in spleen during infection..
MLA	Zhang, Yanhui,et al."Macrophage migration inhibitory factor homolog from Plasmodium yoelii modulates monocyte recruitment and activation in spleen during infection".(2012).

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