QQ客服 官方微博 反馈留言

	Prolyl isomerase Pin1 stabilizes and activates orphan nuclear receptor TR3 to promote mitogenesis
	Chen, H-Z ; Li, L. ; Wang, W-J ; Du, X-D ; Wen, Q. ; He, J-P ; Zhao, B-X ; Li, G-D ; Zhou, W. ; Xia, Y. ; Yang, Q-Y ; Hew, C-L ; Liou, Y-C ; Wu qiao ; Wu Q(吴乔)
	2012-06
关键词	prolyl isomerase pin1 orphan receptor TR3 phosphorylation cell proliferation
英文摘要	Pin1 regulates a subset of phosphoproteins by isomerizing phospho-Ser/Thr-Pro motifs via a 'post-phosphorylation' mechanism. Here, we characterize TR3 as a novel Pin1 substrate, and the mitogenic function of TR3 depends on Pin1-induced isomerization. There are at least three phospho-Ser-Pro motifs on TR3 that bind to Pin1. The Ser95-Pro motif of TR3 is the key site through which Pin1 enhances TR3 stability by retarding its degradation. Pin1 can also catalyze TR3 through phospho-Ser431-Pro motif, which is phosphorylated by extracellular signal-regulated kinase 2 (ERK2), resulting in enhanced TR3 transactivation. Furthermore, Pin1 not only facilitates TR3 targeting to the promoter of cyclin D2, a novel downstream target of TR3, but also promotes TR3 to recruit p300, thereby inducing cell proliferation. Importantly, we found that Pin1 is indispensable for TR3 to promote tumor growth both in vitro and in vivo. Our study thus suggests that Pin1 has an important role in cell proliferation by isomerizing TR3. Oncogene (2012) 31, 2876-2887; doi:10.1038/onc.2011.463; published online 17 October 2011; Ministry of Education, China [B06016]; Ministry of Science and Technology, China [2007CB914402]; National Natural Science Foundation of China [30810103905, 30871281, 31000620]; National Key New Drug Creation Program of China [2009ZX09103-083]; Fundamental Research Funds for the Central Universities, China [2010121096]; Science Planning program grant of Fujian Province, China [2009J1010]; Biomedical Research Council, the Agency for Science, Research and Technology, Singapore [09/1/21/19/604]
语种	英语
出版者	NATURE PUBLISHING GROUP
内容类型	期刊论文
源URL	[http://dx.doi.org/10.1038/onc.2011.463]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Chen, H-Z,Li, L.,Wang, W-J,et al. Prolyl isomerase Pin1 stabilizes and activates orphan nuclear receptor TR3 to promote mitogenesis[J],2012.
APA	Chen, H-Z.,Li, L..,Wang, W-J.,Du, X-D.,Wen, Q..,...&吴乔.(2012).Prolyl isomerase Pin1 stabilizes and activates orphan nuclear receptor TR3 to promote mitogenesis..
MLA	Chen, H-Z,et al."Prolyl isomerase Pin1 stabilizes and activates orphan nuclear receptor TR3 to promote mitogenesis".(2012).

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。