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	Differential Expression of Interleukin 1 Receptor Type II During Mouse Decidualization
	Zhang, Xiu-Hong ; Tian, Zhen ; Lei, Wei ; Zhao, Zhen-Ao ; Wang, Tong-Song ; Yang, Zeng-Ming ; Yang ZM(杨增明)
	2012-09
关键词	uterus embryo implantation decidualization Il1r2
英文摘要	Interleukin 1 (IL-1) is one of the most potent proinflammatory cytokines possessing a wide spectrum of inflammatory, metabolic, hemopoietic, and immunologic properties. In addition, the IL-1 system has been considered relevant in regulating communication between the blastocyst and the endometrium. Interleukin 1 receptor type II (IL1R2) acts as a negative regulator for IL-1 actions and has been termed a "decoy receptor." The aim of this study was to determine the expression pattern of IL1R2 gene in mouse uterus during the early pregnancy. Both in situ hybridization and immunohistochemistry were performed to examine the spatial localization of IL1R2 expression in mouse uteri. Real-time quantitative polymerase chain reaction analyses were used to quantify Il1r2 messenger RNA (mRNA) level under in vivo and in vitro artificial decidualization. By transfecting Il1r2 gene in cultured stromal cells from day 4 pregnant mice, we detected the expression of Dtprp, a well-known marker for decidualization. Our results showed that IL1R2 gene expression was mainly localized in decidual cells close to the implanting embryo during days 5 to 8 of pregnancy. Under in vivo and in vitro artificial decidualization, Il1r2 was significantly upregulated. Dtprp mRNA expression was also upregulated by Il1r2 overexpression. Our data suggest that IL1R2 may play an important role during mouse decidualization.
语种	英语
出版者	SAGE PUBLICATIONS INC
内容类型	期刊论文
源URL	[http://dx.doi.org/10.1177/1933719112438444]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Zhang, Xiu-Hong,Tian, Zhen,Lei, Wei,et al. Differential Expression of Interleukin 1 Receptor Type II During Mouse Decidualization[J],2012.
APA	Zhang, Xiu-Hong.,Tian, Zhen.,Lei, Wei.,Zhao, Zhen-Ao.,Wang, Tong-Song.,...&杨增明.(2012).Differential Expression of Interleukin 1 Receptor Type II During Mouse Decidualization..
MLA	Zhang, Xiu-Hong,et al."Differential Expression of Interleukin 1 Receptor Type II During Mouse Decidualization".(2012).

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